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Dosage and administration
For use in drinking water.
Chickens:
For treatment of respiratory disease associated with Mycoplasma gallisepticum:
The dose is 25 mg tylvalosin per kg bodyweight per day in drinking water for 3 consecutive days.
When used as an aid in reducing the development of clinical signs and mortality (where infection in ovum with Mycoplasma gallisepticum is likely):
The dose is 25 mg tylvalosin per kg bodyweight per day in drinking water for 3 consecutive days at 1 day old. This is followed by a second treatment with 25 mg tylvalosin per kg bodyweight per day in drinking water for 3 consecutive days at the period of risk, i.e. at times of management stress such as administration of vaccines (typically when birds are 2-3 weeks old).
Determine the combined bodyweight (in kg) of all the chickens to be treated. Select the correct number of sachets according to the amount of product required. One sachet of 40 g is sufficient to treat a total of 1,000 kg of chickens (e.g. 20,000 birds with an average bodyweight of 50 g). One sachet of 400 g is sufficient to treat a total of 10 000 kg of chickens (e.g. 20 000 birds with an average bodyweight of 500 g).
In order to achieve a correct dose, the preparation of a concentrated (stock) solution might be required (e.g. to treat a total of 500 kg total bird weight, only 50% of the prepared stock solution prepared from the 40 g sachet should be used).
The product should be added to a volume of water that the chickens will consume in one day. No other source of drinking water should be available during the medication period.
Turkeys:
For treatment of respiratory disease associated with Ornithobacterium rhinotracheale:
The dose is 25 mg tylvalosin per kg bodyweight per day in drinking water for 5 consecutive days. Determine the combined bodyweight (in kg) of all the turkeys to be treated. Select the correct number of sachets according to the amount of product required.
One sachet of 40 g is sufficient to treat a total of 1,000 kg of turkeys (e.g. 10,000 birds with an average bodyweight of 100 g). One sachet of 400 g is sufficient to treat a total of 10,000 kg of turkeys (e.g. 10,000 birds with an average bodyweight of 1 kg).
In order to achieve a correct dose, the preparation of a concentrated (stock) solution might be required (e.g. to treat a total of 500 kg total bird weight, only 50% of the prepared stock solution prepared from the 40 g sachet should be used).
The product should be added to a volume of water that the turkeys will consume in one day. No other source of drinking water should be available during the medication period.
Mixing instructions
The veterinary medicinal product may be mixed directly into the drinking water system or first mixed as a stock solution into a smaller amount of water, which is then added into the drinking water system.
When mixing the product directly into the drinking water system, the contents of the sachet should be sprinkled onto the surface of the water and mixed thoroughly until a clear solution is produced (usually within 3 minutes).
When preparing a stock solution the maximum concentration should be 40 g per 1,500 ml or 400 g of product per 15 litres of water and it is necessary to mix the solution for 10 minutes. After this time, any remaining cloudiness will not affect efficacy of the product.
Only a sufficient amount of medicated drinking water should be prepared to cover the daily requirements. Medicated drinking water should be replaced every 24 hours.
Overdose
No signs of intolerance have been observed in poultry species at up to 150 mg tylvalosin per kg bodyweight per day for 5 days.
No adverse effects on egg production, egg fertility, hatchability and chick viability were observed in broiler breeder stock administered 75 mg tylvalosin per kg bodyweight per day for 28 consecutive days.