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Pharmacological particulars
Pharmacotherapeutic group: live bacterial vaccines for domestic fowl and ducks.
ATCvet code: QI01AE01, QI01BE01, QI01CE01.
AviPro SALMONELLA DUO stimulates active immunity against Salmonella Enteritidis and against Salmonella Typhimurium.
The vaccine strains are natural metabolic drift mutants, i.e. they lack or do not express certain metabolic pathways which result in attenuation.
The genetic basis results in defective ribosomal protein S12 affecting polypeptide synthesis (streptomycin resistance), defective gyrase affecting DNA replication (nalidixic acid resistance) and defective RNA polymerase affecting transcription of DNA to RNA (rifampicin resistance).
The vaccine strains also have attenuations that increase the permeability of the cell membrane for harmful agents such as detergents and antibiotics. This means that the strains have poor survival in the environment and are highly sensitive to fluoroquinolones and unlike field strains are sensitive to erythromycin.