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Date: Sunday, July 27, 2025 2:33

Description: 2015-Elanco-logo
Telephone: 01256 353131 (24 hr response) Veterinary Technical Services
Release 8.118
Fortekor Plus tablets for dogs
 
Species: Dogs
Therapeutic indication: Pharmaceuticals: Cardiovascular and respiratory preparations
Active ingredient: Benazepril Hydrochloride, Pimobendan
Product:Fortekor Plus 1.25 mg/2.5 mg tablets for dogs
Fortekor Plus 5 mg/10 mg tablets for dogs
Product index: Fortekor Plus tablets for dogs
Incorporating:
Qualitative and quantitative composition
Each tablet contains:
Active substances:
Pimobendan
Benazepril hydrochloride
FORTEKOR PLUS 1.25 mg/2.5 mg tablets
1.25 mg
2.5 mg
FORTEKOR PLUS 5 mg/10 mg tablets
5 mg
10 mg
Excipients:
FORTEKOR PLUS 1.25 mg/2.5 mg tablets
Iron oxide brown E172
FORTEKOR PLUS 5 mg/10 mg tablets
0.5 mg
2 mg
For the full list of excipients, see Pharmaceutical Particulars
Pharmaceutical form
Tablets.
White and light brown oval bilayer tablets with a score line on both sides.
The tablets can be divided into equal halves.
Clinical particulars
Target species
Dogs
Indications for use
For the treatment of congestive heart failure due to atrioventricular valve insufficiency or dilated cardiomyopathy in dogs. This veterinary medicinal product is a fixed dose combination and should only be used in patients whose clinical signs are successfully controlled by administration of the same doses of the individual components (pimobendan and benazepril hydrochloride) given concurrently.
Contra-indications
Do not use in cases of hypertrophic cardiomyopathies or clinical conditions where an augmentation of cardiac output is not possible for functional or anatomical reasons (e.g. aortic or pulmonary stenosis).
Do not use in cases of hypotension, hypovolaemia, hyponatraemia or acute renal failure.
Do not use during pregnancy and lactation (see section below).
Do not use in case of hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
None
Special precautions for use
Special precautions for use in the target species
In cases of chronic kidney disease, it is recommended to check the dog’s hydration status before starting therapy, and to monitor its plasma creatinine and blood erythrocyte counts during therapy.
As pimobendan is metabolised in the liver, the veterinary medicinal product should not be administered to dogs with severe hepatic insufficiency.
The efficacy and safety of the veterinary medicinal product has not been established in dogs below 2.5 kg bodyweight or under 4 months of age.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after use.
People with known hypersensitivity to pimobendan or benazepril hydrochloride should avoid contact with the veterinary medicinal product.
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Pregnant women should take special care to avoid accidental oral exposure because angiotensin converting enzyme (ACE) inhibitors have been found to affect the unborn child during pregnancy in humans.
Adverse reactions
Rare
(1 to 10 animals / 10,000 animals treated):
Increased heart rate1
Diarrhoea2, Vomiting1,2
Anorexia2, Lethargy2
Very rare
(<1 animal / 10,000 animals treated, including isolated reports):
Elevated creatinine3
Incoordination2
Fatigue2
2Transient.
3At the start of therapy in dogs with chronic kidney disease. A moderate increase in plasma creatinine concentrations following administration of ACE inhibitors is compatible with the reduction in glomerular hypertension induced by these agents, and is therefore not necessarily a reason to stop therapy in the absence of other signs.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy, lactation or lay
The safety of the veterinary medicinal product has not been established during pregnancy and in lactating dogs.
Pregnancy and lactation:
Do not use in pregnancy or lactation.
Laboratory studies in rats and rabbits with pimobendan have shown foetotoxic effects at maternotoxic doses. Laboratory studies in rats and rabbits with pimobendan have not shown any effect on fertility. Laboratory studies in rats have shown that pimobendan is excreted into milk.
Laboratory studies in rats with benazepril have shown foetotoxic effects (foetal urinary tract malformation) at maternally non-toxic doses. It is not known if benazepril is secreted into the milk of lactating bitches.
Fertility:
Do not use in breeding animals.
Interaction with other medicinal products and other forms of interaction
In dogs with congestive heart failure, benazepril hydrochloride and pimobendan have been given in combination with digoxin and diuretics without demonstrable adverse interactions.
In pharmacological studies no interaction between the cardiac glycoside ouabain and pimobendan was detected. The pimobendan-induced increase in contractility of the heart is attenuated in the presence of the calcium antagonist verapamil and the ß-antagonist propranolol.
In man, the combination of angiotensin converting enzyme (ACE) inhibitors and non-steroidal anti- inflammatory drugs (NSAIDs) can lead to reduced anti-hypertensive efficacy or impaired renal function. Therefore, the concurrent use of the veterinary medicinal product with NSAIDs or any other medications with a hypotensive effect should be considered carefully before using such combinations.
The combination of the veterinary medicinal product and other anti-hypertensive agents (e.g. calcium channel blockers, β-blockers or diuretics), anaesthetics or sedatives may lead to additive hypotensive effects. Renal function and signs of hypotension (lethargy, weakness, etc) should be monitored closely and treated as necessary.
Interactions with potassium-sparing diuretics such as spironolactone, triamterene or amiloride cannot be ruled out. It is therefore recommended to monitor plasma potassium levels when using the veterinary medicinal product in combination with a potassium sparing diuretic because of the risk of hyperkalemia.
Amounts to be administered and administration route
For oral use.
Dose and treatment schedule:
This veterinary medicinal product is a fixed combination product which should only be used in dogs which require both active substances to be administered concomitantly at this fixed dose.
The recommended dose range for this veterinary medicinal product is 0.25–0.5 mg pimobendan per kg bodyweight and 0.5–1 mg benazepril hydrochloride per kg bodyweight divided into two daily doses. This veterinary medicinal product should be administered orally, twice daily 12 hours apart (morning and evening) and approximately 1 hour before feeding.
The tablets are breakable along the score line.
The table below may be used for guidance.
Fortekor Plus
Strength and number of tablets to be administered
Bodyweight (kg) of dog
Fortekor Plus 1.25mg/2.5mg tablets
Fortekor Plus 5mg/10mg tablets
Morning
Evening
Morning
Evening
2.5 - 5
0.5
0.5
5 - 10
1
1
10 - 20
0.5
0.5
20 -40
1
1
Over 40kg
2
2
Overdose
In case of overdose the dog should be treated symptomatically. Transient reversible hypotension may occur in accidental overdose. Therapy should consist of intravenous infusion(s) of warm isotonic saline as required.
Withdrawal periods
Not applicable.
Pharmacological particulars
QC09BX9
Pharmacodynamic properties
Benazepril hydrochloride is a prodrug which is hydrolysed in vivo to its active metabolite, benazeprilat. Benazeprilat is a highly potent and selective inhibitor of ACE, thus preventing the conversion of inactive angiotensin I to active angiotensin II and thereby also reducing the synthesis of aldosterone. Therefore, benazepril blocks effects mediated by angiotensin II and aldosterone, including the vasoconstriction of arteries and veins, the retention of sodium and water by the kidney, and remodelling effects (including pathological cardiac hypertrophy and degenerative renal changes).
In dogs with congestive heart failure benazepril hydrochloride reduces the blood pressure and volume load on the heart. Benazepril increased the time to worsening of heart failure, and the time to death, improved clinical condition, reduced cough and improved exercise tolerance in dogs with symptomatic congestive heart failure caused by valvular disease or dilated cardiomyopathy.
Pimobendan, a benzimidazole-pyridazinone derivative, is a non-sympathomimetic, non-glycoside inotropic substance with potent vasodilating properties. It increases the calcium sensitivity of cardiac myofilaments and inhibits phosphodiesterase (type III). It also exhibits a vasodilatory action through the inhibition of phosphodiesterase type III activity.
Pharmacokinetic properties
Absorption
Following oral administration of pimobendan alone the absolute bioavailability of the active ingredient is 60–63%. Since this bioavailability is considerably reduced when pimobendan is administered with food or shortly thereafter, it is recommended to treat animals approximately 1 hour before feeding.
After oral administration of benazepril hydrochloride alone, the systemic bioavailability is incomplete (~13%) in dogs due to incomplete absorption (38%) and first pass metabolism. Levels of benazepril decline quickly as the drug is partially metabolised by liver enzymes to benazeprilat. There is no significant difference in the pharmacokinetics of benazeprilat when benazepril hydrochloride is administered to fed or fasted dogs.
After the oral administration of the veterinary medicinal product at twice the recommended dose to dogs, peak levels of both compounds are attained rapidly (Tmax 0.5 h for benazepril hydrochloride and 0.85 h for pimobendan) with peak concentrations (Cmax) for benazepril hydrochloride of 35.1 ng/ml and 16.5 ng/ml for pimobendan. Peak benazeprilat levels are seen after 1.9 h with peak concentrations (Cmax) of 43.4 ng/ml.
Distribution
The volume of distribution at steady state is 2.6 l/kg after intravenous administration of pimobendan alone, indicating that pimobendan is distributed readily into the tissues. The mean plasma protein binding in vitro is 93%.
Benazeprilat concentrations decline biphasically: the initial fast phase (t1/2 = 1.7 h) represents elimination of the free drug, while the terminal phase (t1/2 = 19 h) reflects the release of benazeprilat that was bound to ACE, mainly in the tissues. Benazepril and benazeprilat are extensively bound to plasma proteins (85–90%), and in the tissues they are found mainly in the lung, liver and kidney.
Repeated administration of benazepril hydrochloride leads to slight bioaccumulation of benazeprilat (R = 1.47), steady state being achieved within a few days (4 days).
Metabolism
Pimobendan is oxidatively demethylated to its major active metabolite, O-desmethyl pimobendan. Further metabolic pathways are phase II, glucuronides and sulfates.
Benazepril hydrochloride is partially metabolised by liver enzymes to the active metabolite benazeprilat.
Elimination
The plasma elimination half-life of pimobendan when dosed with this veterinary medicinal product is 0.5 h, consistent with the high clearance of the compound. The main active metabolite of pimobendan is eliminated with a plasma elimination half-life of 2.6 h. Pimobendan is excreted principally in the faeces and to a lesser extent in the urine.
The plasma elimination half-life of benazepril hydrochloride and benazeprilat, when dosed with this veterinary medicinal product is 0.36 h and 8.36 h, respectively. Benazeprilat is excreted via the biliary (54%) and urinary (46%) routes in dogs. The clearance of benazeprilat is not affected in dogs with impaired renal function; therefore no adjustment of the dose is required in dogs with renal insufficiency.
Pharmaceutical particulars
Excipients
Artificial Special Dry Flavour
Basic butylated methacrylate copolymer
Copovidone
Croscarmellose sodium
Crospovidone
Dibutyl sebacate
Hypromellose
Iron oxide brown E172
Lactose monohydrate
Magnesium stearate
Maize starch
Microcrystalline cellulose
Polysorbate 80
Povidone
Silica, colloidal anhydrous
Silicon dioxide anhydrous
Sodium laurilsulfate
Starch pregelatinised
Succinic acid
Sucrose
Major incompatibilities
Not applicable.
Shelf life
GB: Shelf life of the veterinary medicinal product as packaged for sale: 2 years
NI: 18 months (change to 2 years approved, but not yet implemented)
Shelf life after first opening the immediate packaging: 1 day
Special precautions for storage
Store below 25 °C.
Keep the blister in the outer carton in order to protect from moisture.
Any remaining half tablet should be placed back in the opened blister and stored (for a maximum of 1 day) in the original cardboard carton.
Immediate packaging
The tablets are packaged in aluminium/aluminium blisters packaged into an outer cardboard box.
Pack sizes:
Cardboard box containing 30 tablets
Cardboard box containing 60 tablets
Not all pack sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Marketing Authorisation Holder (if different from distributor)
Elanco GmbH
Heinz-Lohmann-Str. 4
27472 Cuxhaven
Germany
Marketing Authorisation Number
Fortekor Plus 1.25 mg/2.5 mg Tablets
UK (Great Britain): Vm 52127/5014
UK (Northern Ireland): EU/2/15/185/001-002
Fortekor Plus 5 mg/10 mg Tablets
UK (Great Britain): Vm 52127/5015
UK (Northern Ireland): EU/2/15/185/003-004
Significant changes
Date of the first authorisation or date of renewal
Date of first authorisation: 08/09/2015
Date of revision of the text
13 Oct 2023
Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu/ .
Any other information
Nil
Legal category
Legal category: POM-V
GTIN
GTIN description:FORTEKOR PLUS 1.25 mg/2.5 mg tablets for dogs (1 x 30 tablets)
GTIN:05014602803773
GTIN description:FORTEKOR PLUS 5 mg/10 mg tablets for dogs (1 x 30 tablets)
GTIN:05014602803780