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Clinical particulars
Target species
Pigs and Cattle
Indications for use
Infections associated with bacteria sensitive to Ceftiofur:
- Treatment of bacterial respiratory disease associated with Pasteurella multocida, Actinobacillus pleuropneumoniae and Streptococcus suis.
- For the treatment of bacterial respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida and Histophillus somni.
- For the treatment of acute interdigital necrobacillosis (panaritium, foot rot) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus (Phorphyromonas asaccharolytica).
- For the treatment of the bacterial component of acute post-partum (puerperal) metritis within 10 days after calving associated with Escherichia coli, Arcanobacterium pyogenes and Fusobacterium necrophorum. (restricted to cases where treatment with another antimicrobial has failed).
Do not administer to an animal previously found to be hypersensitive to Ceftiofur and other β-lactam antibiotics.
Do not inject intravenously.
Do not use in poultry (including eggs) due to risk of spread of antimicrobial resistance to humans.
Special warnings for each target species
None known.
Special precautions for use
i) Special precautions for use in animals
Shake the bottle well before use to bring the product back into suspension.
In case of the occurrence of allergic reaction the treatment should be withdrawn.
Inappropriate use of the product may increase the prevalence of bacteria resistant to cephalosporins.
Use of the product should be based on susceptibility testing and take into account official and local antimicrobial policies.
Do not use for disease prevention or as a part of herd health programmes. Treatment of groups of animals should be strictly restricted to ongoing disease outbreaks according to the approved conditions of use.
Do not use as prophylaxis in case of retained placenta.
ii) Special precaution to be taken by the person administering the medicinal product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
People with known hypersensitivity to penicillins or cephalosporins should avoid contact with the product.
In the case of accidental self-injection or following exposure, if you develop symptoms such as a skin rash, seek medical advice immediately and show the package leaflet or the label to the physician.
Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.
Adverse reactions
Hypersensitivity reactions unrelated to dose can occur. Allergic reactions (e.g. skin reactions, anaphylaxia) may occasionally occur.
In swine, mild reactions at the injection site, such as discoloration of the fascia or fat, have been observed in some animals for up to 20 days after injection.
In cattle, mild inflammatory reactions at the injection site, such as tissue oedema and discoloration of the subcutaneous tissue and/or fascial surface of the muscle may be observed. Clinical resolution is reached in most animals by 10 days after injection although slight tissue discoloration may persist for 28 days or more.
Use during pregnancy, lactation or lay
Studies in laboratory species have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. Safety has not been established in the target species during pregnancy. Use only according to the benefit/risk assessment by the responsible veterinarian.
The bacterial properties of β-lactams are neutralised by simultaneous use of bacteriostatic antibiotics (macrolides, sulphonamides and tetracyclines).
Amounts to be administered and administration route
3 mg Ceftiofur/kg bw/day for 3 days by intramuscular injection, i.e. 1 ml of the product /16 kg bw/day.
Treatment of respiratory disease: 1 mg Ceftiofur/kg bw/day for 3 to 5 days by subcutaneous injection, i.e. 1 ml of the product /50 kg bw/day.
Treatment of acute interdigital necrobacillosis: 1 mg Ceftiofur/kg bw/day for 3 days by subcutaneous injection, i.e. 1 ml of the product/50 kg bw/day.
Acute post-partum metritis within 10 days after calving: 1 mg Ceftiofur/kg bw/day for 5 consecutive days by subcutaneous injection, i.e. 1 ml of the product /50 kg bw/day.
Subsequent injections must be given at different sites.
In case of acute post-partum metritis, additional supportive therapy might be required in some cases.
Shake well before use.
The low toxicity of Ceftiofur has been demonstrated in swine using Ceftiofur sodium at doses in excess of 8 times the recommended daily dose of Ceftiofur intramuscularly administered for 15 consecutive days.
In cattle, no signs of systemic toxicity have been observed following substantial parenteral overdosages.
Withdrawal periods
- Meat and offal: 5 days.
- Meat and offal: 8 days
- Milk: zero days.