Pharmacodynamic properties
Tylosin is a macrolide antibiotic produced by a strain of Streptomyces fradiae. It exerts its antimicrobial effect by inhibiting protein synthesis of susceptible micro-organisms.
The tylosin spectrum of activity includes amongst others Gram-positive bacteria, some Gram–negative strains such as Pasteurella, and Mycoplasma spp.
Pharmacokinetic properties
In most species peak plasma concentrations have been attained 1 to 2 hours after administration of tylosin. Compared to plasma levels clearly higher tissue concentrations have been observed. Tylosin was extensively metabolised.
Most of the residues are excreted in faeces predominantly consisting of tylosin (factor A), relomycin (factor D) and dihydrodesmycosin