Horses and donkeys.
Indications for use
The product is indicated for the treatment of parasitic infestations in horses and donkeys due to:
Strongylus vulgaris (adults and arterial larval stages)
S. edentatus (adults and tissue larval stages)
S. equinus (adults)
Triodontophorus spp. (adults)
Craterostomum acuticaudatum (adults)
Adult and immature (fourth stage larvae) small strongyles or cyathostomes, including benzimidazole-resistant strains:
Lungworms (adult and immatures)
Pinworms (adult and immatures)
Ascarids (adults and third and fourth stage larvae)
Large-mouth stomach worms (adults)
Neck threadworms (microfilariae)
Adult intestinal threadworms
Oral and, gastric stages of bots:
The product has been formulated for use in horses and donkeys only. Dogs and cats may be adversely affected by the concentration of ivermectin in this product if they are allowed to ingest spilled paste or have access to used syringes.
Special warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
- Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Resistance to macrocyclic lactones (which includes ivermectin) has been reported in Parascaris equorum in horses in a number of countries within the EU. Therefore, the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of gastrointestinal nematodes and recommendations on how to limit further selection for resistance to anthelmintics.
Special precautions for use in animals
No special precautions are required.
Special precautions to be taken by the person administering the product
Do not smoke, eat or drink while handling the product.
Wash hands after use.
This product may cause skin and eye irritation. Therefore, the user should avoid contact of the product with the skin and the eyes. In the case of contact, rinse immediately with plenty of water.
In the case of accidental ingestion or eye irritation after contact seek medical advice immediately and show the package insert or the label to the physician.
Adverse reactions (frequency and seriousness)
Some horses carrying heavy infection of Onchocerca microfilariae have experienced oedema and pruritus following dosing, assumed to be the result of death of large numbers of microfilariae. These signs resolve within a few days but symptomatic treatment may be advisable.
Use during pregnancy, lactation or lay
Horses and donkeys of all ages, including pregnant mares and breeding stallions, have been treated with no adverse effect.
Interaction with other medicinal products and other forms of interaction
The product has been used in conjunction with other equine health care products and no interactions have been identified.
Amounts to be administered and administration route
Administer orally to both horses and donkeys at the recommended dose level of 0.2 mg ivermectin per kilogram of bodyweight.
Bodyweight and dosage should be accurately determined prior to treatment. For syringes intended to treat horses up to 600 kg and 1100 kg calibrated markings are provided at 100 kg bodyweight intervals. For the syringe intended to treat horses up to 750 kg, calibrated markings are provided at 125 kg bodyweight intervals. The syringe should be adjusted to the calculated dosage by setting the ring on the appropriate place on the plunger
Unlock the knurled ring by making a ¼ turn and slide the knurled ring up the plunger shaft so that the side nearest the barrel is at the prescribed weight marking. Turn the knurled ring ¼ turn to lock in place. Remove the plastic cap from the tip of the nozzle. Make sure the horse’s mouth contains no feed. Insert the syringe into the horse’s mouth at the interdental space. Advance the plunger as far as it will go, depositing the medication on the base of the tongue.
Parasite control program
Veterinary advice should be given on appropriate dosing programs and stock management to achieve adequate parasite control for both tapeworm and roundworm infestations. Foals may be treated initially at 6-8 weeks of age if indicated. Discard any unused material.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Mild transitory signs (slowed pupillary light response and depression) have been seen at a dose of 1.8 mg/kg (9 times the recommended dose level). Other signs seen at higher doses include mydriasis, ataxia, tremors, stupor, coma and death. The less severe signs have been transitory. No antidote has been identified; however, symptomatic therapy may be beneficial.
Donkeys – meat: 21 days
Horses – meat: 21 days
Do not use in mares producing milk for human consumption