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Pharmacotherapeutic group
Antineoplastic and immunomodulating agents, other immunostimulants.
ATCvet code: QL03AX.
The vaccine strain vCP1338 is a recombinant canarypox virus expressing feline interleukin-2 (IL-2). The virus expresses the IL-2 gene at the inoculation site, but does not replicate in the cat.
Oncept IL-2 injected into the tumour bed thus delivers in situ a low dose of feline interleukin-2, which stimulates antitumour immunity while avoiding toxicity associated with systemic treatment. Specific mechanisms by which immunostimulation induces anti-tumoural activity are not known.
In a randomised clinical study, cats from different origins presenting a fibrosarcoma without metastasis or lymph node involvement were included in two groups, one receiving the reference treatment – surgery and radiotherapy – and the other receiving Oncept IL-2 in addition to surgery and radiotherapy. After two years of study follow-up, Oncept IL-2 treated cats showed a longer median time to relapse (above 730 days) compared to control cats (287 days). Oncept IL-2 treatment reduced the risk of relapse, from 6 months after the start of treatment, by approximately 56% after 1 year and 65% after 2 years.