Per 1ml:

Ivermectin 10 mg

For the full list of excipients, see below.

Solution for injection.

Cattle, sheep and pigs.

PANOMEC Injection for Cattle, Sheep and Pigs is indicated for the effective treatment and control of the following harmful parasites of cattle, sheep and pigs.

Trichuris spp.

Thelazia spp.

Sarcoptes scabiei var. bovis

Panomec Injection for Cattle, Sheep and Pigs may also be used as an aid in the control of biting lice (Damalinia bovis) and the mange mite Chorioptes bovis, but complete elimination may not occur.

Panomec Injection for Cattle, Sheep and Pigs given at the recommended dosage of 0.2 mg per kg bodyweight controls re-infection with Barbers pole worm (Haemonchus placei), Small intestinal worm (Cooperia spp.) and Hairworm (Trichostrongylus axei) for 14 days, Brown stomach worm (Ostertagia ostertagi) and Nodular worm (Oesophagostomum radiatum) for 21 days, and Lungworm (Dictyocaulus viviparus) for 28 days after treatment.

The timing of treatment should be based on epidemiological factors and should be customised for each individual farm. A dosing program should be established by a qualified professional person.

*For the treatment and control of sheep scab, two injections with a seven-day interval are required to treat clinical signs of scab and to eliminate mites.

Oesophagostomum spp.

Metastrongylus spp.

Do not use intramuscularly or intravenously.

PANOMEC Injection for Cattle, Sheep and Pigs has been formulated specifically for use in these target species. Do not use in other species as severe adverse reactions, including fatalities in dogs, may occur.

Details provided elsewhere apply. See also Indications, Contra-indications, and Special Precautions for Use

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

Resistance to macrocyclic lactones (which includes ivermectin) has been reported in Teladorsagia spp. in sheep and in Cooperia spp. in cattle within the EU. Therefore, the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

In sheep treatment of psoroptic mange (sheep scab) with one injection is not recommended because, although a clinical improvement may be seen, elimination of all mites may not occur.

Sheep scab (Psoroptes ovis) is an extremely contagious external parasites of sheep. Following treatment of infected sheep, great care must be taken to avoid re-infestation, as mites may be viable for up to 15 days off the sheep. It is important to ensure all sheep which have been in contact with infected sheep are treated.

Contact between treated infected and non-treated, non-infected flocks must be avoided until at least 7 days after the last treatment.

Take care to avoid self-injection: the product may cause local irritation and/or pain at the injection site. Do not smoke, eat or drink while handling the product. Wash hands after use. In case of accidental self-injection, seek medical advice and show the label or package leaflet to the physician.

Transitory discomfort has been observed in some cattle following subcutaneous administration. A low incidence of soft tissue swelling at the injection site has been observed.

Immediately following subcutaneous injection, activity suggesting pain, sometimes intense but usually transient, has been observed in some sheep.

Mild and transient pain reactions may be seen in some pigs following subcutaneous injection. All these reactions disappeared without treatment.

PANOMEC Injection for Cattle, Sheep and Pigs can be administered to cows and ewes at any stage of pregnancy or lactation provided that the milk is not intended for human consumption, and to sows at any stage of pregnancy or lactation. It can be used in breeding ewes, rams, sows and boars and will not affect fertility. PANOMEC Injection for Cattle, Sheep and Pigs can be given to all ages of animals including young calves, lambs and piglets. See also 'Special warnings for each target species'.

PANOMEC Injection for Cattle, Sheep and Pigs has been used concurrently without adverse effects with foot and mouth disease vaccine or clostridial vaccine, given at separate injection sites. Adequate vaccination of sheep against clostridial infections is strongly recommended.

PANOMEC Injection for Cattle, Sheep and Pigs should be given only by subcutaneous injection at the recommended dosage level of 200 mcg ivermectin per kg bodyweight under the loose skin in front of, or behind, the shoulder in cattle and in the neck in sheep. At the recommended dosage level of 300 mcg ivermectin per kg bodyweight, PANOMEC Injection for Cattle, Sheep and Pigs should be given only subcutaneously in the neck in pigs.

Syringes must be filled from the vial through a dry sterile draw-off needle that has been placed in the vial stopper. Vial stoppers must not be broached more than 20 times.

This product does not contain an antimicrobial preservative. Swab septum before removing each dose. Use sterile needle and syringe. When treating groups of animals use only an automatic dosing device (with vented draw-off apparatus when using the 50 ml vial). To ensure administration of a correct dose, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked.

Use this chart as a guide in working out the appropriate dose rate:

When treating pigs and sheep of less than 16 kg, seek veterinary advice regarding the use of 1 ml disposable syringes graduated in increments of 0.1 ml. When treating individual sheep, a syringe, not exceeding 2 ml and calibrated in increments of 0.1 ml, should be used.

Each ml contains 10 mg of ivermectin sufficient to treat 50 kg of bodyweight of cattle and sheep and 33 kg of bodyweight of pigs. The injection may be given with any standard automatic or single-dose or hypodermic syringe. Use of 17 gauge x ½ inch needle is suggested.

Replace with a fresh sterile needle after every 10 to 12 animals. Injection of wet or dirty animals is not recommended. For the treatment and control of sheep scab (Psoroptes ovis), two injections with a seven-day interval are required to treat clinical signs of scab and to eliminate mites.

Cattle: Single doses of 4.0 mg ivermectin per kg (20 x the use level) given subcutaneously resulted in ataxia and depression.

Sheep: At oral dose levels up to 4 mg ivermectin per kg (20 x the use level) given subcutaneously resulted in ataxia and depression.

Pigs: A dose of 30 mg ivermectin per kg (100 x the recommended dose of 0.3 mg per kg) injected subcutaneously to pigs caused lethargy, ataxia, bilateral mydriasis, intermittent tremors, laboured breathing and lateral recumbency.

No antidote has been identified; however, symptomatic therapy may be beneficial.

Cattle (meat and offal): 49 days

Cattle (milk): Do not use in cattle producing milk for human consumption. Do not use in non-lactating dairy cows, including pregnant heifers, within 60 days of calving.

Sheep (meat and offal): 37 days

Sheep (milk): Do not use in sheep producing milk for human consumption.

Pigs (meat and offal): 19 days.

Glycerol Formal, Propylene Glycol

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products

Shelf life of the veterinary medicinal product as packaged for sale: 5 years.

Shelf-life after first opening the immediate packaging: 6 months.

Protect from direct sunlight and store below 30 °C. Keep out of reach of children. This product does not contain any antimicrobial preservative. Following withdrawal of the first dose, use the product within 6 months. Discard unused material

50 ml polyethylene bottles.

EXTREMELY DANGEROUS TO FISH AND AQAUTIC LIFE. Do not contaminate ponds, waterways or ditches with product or empty containers. Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.