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Clinical particulars
Target species
Rainbow trout (Oncorhynchus mykiss).
Indications for use
Active immunization against Enteric Redmouth disease (ERM) to reduce mortality caused by Hagerman type 1 and EX5 biotype strains of Yersinia ruckeri.
Immersion route
Onset of immunity: 336 degree days (28 days at 12 °C) for Hagerman type 1 and for EX5 biotype.
Duration of immunity: 6 months (205 days at 12 °C) for the Hagerman type 1.
4 months (133 days at 12 °C) for the EX5 biotype.
Please note that the level of protection against the EX5 biotype wanes during the indicated period.
Injection route (only for booster vaccination)
Duration of immunity: Immunity has not been studied beyond 28 days (336 degree days).
Special warnings for each target species
The minimum weights for fish before vaccination must be respected (see section "Amounts to be administered and administration route").
Special precautions for use
Only vaccinate healthy fish. Do not vaccinate if the water temperature is below 12°C. Avoid stress at the time of the handling of fish, as well as temperature variations, in particular between the vaccine suspension and the water of the holding area.
Operator warnings
Protective equipment should be used to avoid self injection. In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.
Adverse reactions
Injection administration can induce very slight adhesions (Speilberg score 1) at the site of injection, which may persist for 7 weeks but are normally no longer observed 3 months after injection.
Use during pregnancy or lactation
Do not administer to broodstock or fish intended as broodstock.
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
Amounts to be administered and administration route
Primary vaccination should be by the immersion route only. In the event that a booster vaccination is required to extend the duration of immunity for a further 28 days then the injection route should be used. When administering by immersion, dilute the contents immediately after opening the container, and use diluted vaccine immediately. The development of protective immunity is dependant on the water temperature. Shake the bottle before use.
Primary vaccination by immersion (Fish of ≥ 5 g)
Dilute the contents of the bottle (1 litre) in 9 litres of hatchery water, clean and suitably oxygenated.Place the fish into batches and immerse for 30 seconds in the diluted vaccine. A litre of vaccine (making 10 litres of diluted vaccine) allows the vaccination of a maximum of 100 kg of fish.
Booster vaccination by injection (Fish of ≥ 12 g)
The vaccine must be administered using a multi-dose injection applicator incorporating a mechanism to prevent flush-back. This applies equally to hand-held and automatic systems. The product is administered by intra-peritoneal injection in the ventral area, just anterior to the pelvic fins. The dose is 0.1 ml per fish. The fish should be anaesthetised prior to vaccination.
No adverse effects have been noted following a double dose of vaccine by immersion or injection.
Withdrawal period
Zero degree days.