Target species
Cattle (lactating cows).
Indications for use
For the treatment of clinical mastitis in the lactating dairy cow caused by the following cefquinome sensitive organisms: Staphylococcus aureus, Streptococcus uberis, Streptococcus dysgalactiae, and Escherichia coli.
Contraindications
Do not use in cases of hypersensitivity to cephalosporin antibiotics and other beta-lactam antibiotics.
Do not use the cleaning towel if lesions are present on the teat.
Special warnings for each target species
None.
Special precautions for use
Use of the veterinary medicinal product should be based on identification and susceptibility testing of the target pathogen(s) and take into account official and local antimicrobial policies. Inappropriate use of the veterinary medicinal product may increase the prevalence of bacteria resistant to cefquinome and may decrease the effectiveness of treatment with cephalosporins, due to the potential for cross-resistance.
Operator warnings
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross sensitivity to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
Handle this veterinary medicinal product with great care to avoid exposure, taking all recommended precautions.
People with known hypersensitivity to penicillins and cephalosporins should avoid contact with the veterinary medicinal product.
If you develop symptoms following exposure, such as a skin rash, seek medical advice immediately and show the package leaflet or the label to the physician. Swelling of the face, lips and eyes or difficulty breathing are more serious symptoms and require urgent medical attention.
Wash hands after using the cleaning towels and wear protective gloves if skin irritation due to isopropyl alcohol is known or suspected.
Adverse reactions
Cattle (lactating cows):
Very rare (<1 animal / 10,000 animals treated, including isolated reports): | Anaphylaxis |
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy or lactation
The veterinary medicinal product is intended for use during lactation. There is no available information indicating reproductive toxicity (including teratogenicity) in cattle. In reproductive toxicity studies in laboratory animals cefquinome did not reveal any effect on reproduction or teratogenic potential.
Interactions
It is known that a cross sensitivity to cephalosporins exists for bacteria sensitive to the cephalosporin group.
Amounts to be administered and administration route
Intramammary use.
The contents of one syringe should be infused gently into the teat of the infected quarter every 12 hours after each of three successive milkings.
Milk out the affected quarter(s). After thoroughly cleaning and disinfecting the teat and teat orifice with the cleaning towel provided, gently infuse the contents of one syringe into each affected quarter. Disperse the product by gentle massage of the teat and udder of the affected animal.
The syringe must only be used once. Partly used syringes should be discarded.
Overdose
No symptoms expected or emergency procedures required.
Withdrawal periods
Meat and offal: 4 days.
Milk: 5 days (120 hours).