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Clinical particulars
Target species
Dogs and cats.
Indications for use
For the active immunisation against rabies to reduce clinical signs and mortality.
Onset of immunity: an adequate serological response (≥ 0.5 I.U.) has been demonstrated 2 to 3 weeks after vaccination.
Duration of immunity: 3 years.
Do not use in unhealthy animals. The vaccine may not be effective in animals incubating the disease at the time of vaccination.
Some animals may be immunologically incompetent and fail to respond to vaccination (see further information). Animals that have received the corresponding anti-serum or immunosuppressive drugs should not be vaccinated until an interval of at least 4 weeks has elapsed.
Special warnings for each target species
Special precautions for use
The presence of maternal antibodies can interfere with the response to vaccination.
Operator warnings
Adverse Reactions
Transient local reactions such as non-painful diffuse to firm swellings of approximately 1 cm in diameter may be observed for up to 3 weeks after subcutaneous vaccination.
In the rare event of a hypersensitivity reaction following vaccination, administer an antihistamine, corticosteroid or adrenaline, without delay and by the most immediate route.
Use during pregnancy and lactation
Can be used during pregnancy in dogs. There are no laboratory data on use during pregnancy in other species, but on basis of field experience, such use is expected to be safe.
Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with vaccines of the Nobivac range containing one or more of the following: live canine distemper, canine adenovirus, canine parvovirus and canine parainfluenza and inactivated canine leptospirosis antigens Leptospira canicola and icterohaemorrhagiae or live feline viral rhinotracheitis virus, feline calicivirus and feline panleucopenia virus.
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product except the products mentioned above. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
This product should not be given for at least one month following the administration of hyperimmune serum or immunosuppressant drugs.
Amount to be administered and administration route
A single dose inoculation of 1 ml is sufficient irrespective of size, species or breed of animal. Sterile equipment should be used for administration. Avoid contamination of vaccine with traces of chemical sterilising agents. Do not use chemicals such as disinfectant or spirit to disinfect the skin prior to inoculation.
Primary course and booster vaccination
Dogs & cats
Primary vaccination age* 12 weeks or older
Booster vaccination every 3 years
Route of administration intramuscularly or subcutaneously
* Primary vaccination may be administered at an earlier age (minimum in dogs and cats of 4 weeks of age), but then a repeat vaccination must be given at the age of 12 weeks.
Health regulations and requirements in certain countries specify that dogs must be revaccinated annually against rabies.
Further information
Limited safety data for ferrets are available from monitoring post vaccination reactions. Ferrets can be vaccinated subcutaneously from 12 weeks of age. An adequate serological response (≥ 0.5 I.U.) has been demonstrated 1 month after vaccination and they should receive a booster vaccination every 18 months.
A good immune response is reliant on the reaction of an immunogenic agent and a fully competent immune system. Immunogenicity of the vaccine antigen will be reduced by poor storage or inappropriate administration. Immuno-competence of the animal may be compromised by a variety of factors including poor health, nutritional status, genetic factors, concurrent drug therapy and stress.
Pet Travel Scheme (PETS)
Animals intended for vaccination under the Pet Travel Scheme (PETS) must be identified by a permanent numbered microchip. This microchip number must be recorded on the record of the dog, cat and ferret vaccination at the time of rabies vaccination.
No effects other than those in section "Adverse reactions".
Withdrawal period
Not applicable.