Target species
Pigs and chickens.
Indications for use
Pigs:
Treatment and control of gastro-intestinal nematodes in pigs infected with:
- Ascaris suum (adult, intestinal and migrating larval stages)
- Oesophagostomum spp. (adult stages)
- Trichuris suis (adult stages)
Chickens:
Treatment of gastro-intestinal nematodes in chickens infected with:
- Ascaridia galli (L5 and adult stages)
- Heterakis gallinarum (L5 and adult stages) - Capillaria spp. (L5 and adult stages)
Contraindications
None.
Special warnings for each target species
Parasitic resistance to any particular class of anthelmintic may develop following frequent repeated use of an anthelmintic of that class.
Special precautions for use
In the absence of available data, treatment of chickens less than 3 weeks of age should be based on a benefit/risk assessment by the responsible veterinarian.
Operator warnings
This veterinary medicinal product may be toxic to humans after ingestion. Embryotoxic effects cannot be excluded. Pregnant women must take extra precautions when handling this veterinary medicinal product.
Avoid contact with skin, eye and mucous membranes. People with known hypersensitivity to fenbendazole should avoid contact with the veterinary medicinal product.
Personal protective equipment consisting of gloves should be worn when handling the veterinary medicinal product and cleaning the measuring device. Wash hands after use.
In case of accidental spillage onto skin and/or eye, immediately rinse with plenty of water. Remove contaminated clothes after spillage.
Other precautions
The veterinary medicinal product should not be allowed to enter surface waters as it has harmful effects on aquatic organisms.
Adverse reactions
None known.
Use during pregnancy or lactation
Can be used during pregnancy, lactation or lay.
Interactions
None known.
Amounts to be administered and administration route
In drinking water use.
To ensure administration of the correct dose, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked.
Before allowing animals to have access to the medicated water, the water delivery system should be drained, if possible, and flushed with the medicated water to ensure accuracy of dosing. This procedure may need to be performed on all treatment days.
Pigs:
The dose is 2.5 mg fenbendazole per kg body weight per day (equivalent to 0.0125 ml Panacur AquaSol). For the treatment and control of Ascaris suum and Oesophagostomum spp. this dose has to be administered on 2 consecutive days. For the treatment and control of Trichuris suis the dose has to be administered on 3 consecutive days.
Dose calculation:
The required daily amount of product is calculated from the total estimated body weight (kg) of the entire group of pigs to be treated. Please use the following formula:
Total estimated body weight (kg) of pigs to be treated x 0.0125 ml = ml product/day |
Examples (See also Dosage Calculation Schedule for pigs):
Panacur Aquasol Dosage Calculation Schedule for pigs |
Total body weight of pigs to be treated | Day 1 amount of product | Day 2 amount of product | Day 3 amount of product | Total amount (for 2 days) | Total amount (for 3 days) |
| | | | | |
| | | | | |
80,000 | 1,000 ml | 1,000 ml | 1,000 | 2 x 1,000 ml | 3 x 1,000 ml |
320,000 | 4,000 ml | 4,000 ml | 4,000 | 2 x 4,000 ml | 3 x 4,000 ml |
Chickens:
Ascaridia galli and Heterakis gallinarum: 1 mg fenbendazole per kg body weight per day (equivalent to 0.005 ml Panacur AquaSol) for 5 consecutive days.
Capillaria spp.: 2 mg fenbendazole per kg body weight per day (equivalent to 0.01 ml Panacur AquaSol) for 5 consecutive days.
Dose calculation:
The required daily amount of product is calculated from the total estimated body weight (kg) of the entire group of chickens to be treated. Please use the following formula:
Treatment of Ascaridia galli and Heterakis gallinarum:
Total estimated body weight (kg) of chickens to be treated x 0.005 ml = ml product/day |
Treatment of Capillaria spp.
Total estimated body weight (kg) of chickens to be treated x 0.01 ml = ml product/day |
Examples:Panacur AquaSol Dosage Calculation Schedule for chickens
Total bodyweight of chickens to be treated | Amount of product per day for 1 mg FBZ/kg (ml/day) | Total amount of product (ml/for 5 days) |
40,000 kg | 200 ml | 1,000 ml |
| | (5 x 200 ml) |
160,000 kg | 800 ml | 4,000 ml |
| | (5 x 800 ml) |
Total bodyweight of chickens to be treated | Amount of product per day for 2 mg FBZ/kg (ml/day) | Total amount of product (ml/for 5 days) |
40,000 kg | 400 ml | 2,000 ml |
| | (5 x 400 ml) |
160,000 kg | 1600 ml | 8,000 ml |
| | (5 x 1600 ml) |
Follow the instructions in the order described below to prepare the medicated water. Use a sufficiently accurate measuring device, which should be properly cleaned after use.
For each treatment day the medicated water needs to be freshly prepared.
Prepare a predilution of the veterinary medicinal product with an equal amount of water:
•Select a measuring device that has at least double volume of the calculated daily product volume.
•Pour a volume of water equal to the calculated volume of product needed into the measuring device.
•Shake the product well before mixing.
•Fill up the measuring device containing the water with the calculated volume of the product to obtain the predilution.
•Add the obtained predilution to the water supply system as described below.
For use in medication tank:
Add the entire content of the measuring device (predilution) to the volume of drinking water usually consumed by the animals in between 3 to 24 hours.
Stir until content in the medication tank is visibly homogeneous. The medicated water appears hazy.
No further stirring during administration is necessary.
For use in dosing pump:
Add the entire content of the measuring device (predilution) to the unmedicated water in the stock suspension container of the dosing pump. The volume of unmedicated water in the stock suspension container has to be calculated taking as a basis the preset injection rate of the dosing pump and the volume of drinking water usually consumed by the animals in between 3 and 24 hours.
Stir until content in the stock suspension container is visibly homogeneous. The medicated water appears hazy.
At concentrations of up to 5 ml/l stock suspension (1 g fenbendazole/l) no stirring is required.
At concentrations above 5 ml/l stock suspension and up to 75 ml/l stock suspension (15 g fenbendazole/l) and within an administration period of up to 8 hours no stirring of the stock suspension is required. If the administration period exceeds 8 hours, but being no longer than 24 hours, the stock suspension container needs to be equipped with a stirring device.
During treatment all animals must have solely but unrestricted access to the medicated water.
During treatment, after complete consumption of the medicated water, animals must be allowed access to unmedicated drinking water as soon as possible.
Ensure that the total amount of medicated water offered is consumed.
Overdose
Pigs:
No adverse reactions have been observed at up to ten-fold overdose in pigs.
Chickens:
No adverse reactions have been observed at up to 2.5-fold the maximum recommended dose of 2 mg fenbendazole/ kg body weight in layers and broilers (aged 21 days). A transient mild to moderate reduction in bone marrow cellularity accompanied by a transient reduction in peripheral white blood cell counts and heterophils was observed in 4 out of 12 chickens administered an overdose of 10 mg fenbendazole/kg bodyweight for 21 consecutive days. No adverse reactions have been observed at up to 1.5-fold the maximum recommended dose of 2 mg fenbendazole/ kg body weight in breeders. No detrimental effects on hatchability and chick viability were evident. Higher overdoses have not been tested.
Withdrawal periods
Pigs
Meat and offal: 4 days.
Chickens
Meat and offal: 6 days for 1 mg fenbendazole /kg dose;
9 days for 2 mg fenbendazole /kg dose.
Eggs: zero days.