ATCvet code: QH01CA90.
Pharmacotherapeutic group
Gonadotrophin-releasing hormone.
Pharmacodynamic properties
Buserelin is a synthetic analogue of gonadotrophin releasing hormone (GnRH) which controls luteinising hormone (LH) and the follicle stimulating hormone (FSH) concentrations. As FSH and LH play a key role in the final maturation of the preovulatory follicle, buserelin has the ability to induce and synchronise ovulation, induce turn over of the cystic follicles and improve conception rate.
Pharmacokinetic properties
Cattle: Following buserelin injection, peak concentrations in blood are achieved 1 hour later. Six hours after injection, plasma buserelin concentrations are back to basal levels. Higher amounts than the recommended clinical doses do not further increase LH and FSH concentrations.
Pigs: Following administration of Buserelin, peak LH concentration in blood was observed at 1.7 hours post injection. Data clearly confirmed that absorption is also rapid in pigs. Buserelin is rapidly eliminated. Following injection, it accumulates in liver, kidneys and pituitary. The quick inactivation of buserelin by enzymatic breakdown (peptidases) takes place in hypothalamus and pituitary as well as in the liver and kidneys. All metabolites are small inactive peptides.