Do not vaccinate sick or immunodeficient animals.
No side effects other than those listed below are expected when the vaccine is used between 8 and 2 weeks prior to parturition. In the absence of specific data, the use of the vaccine during the first or second trimester of pregnancy should be avoided. Avoid stress in pregnant ewes and cows.
Clinical trials have demonstrated that the presence of maternal antibodies against C. chauvoei may reduce the antibody response to vaccination in young lambs. Therefore, to ensure an optimal response in young animals with high levels of MDA, the primary vaccination should be delayed until the levels wane (which is after about 8-12 weeks of age).
In the event of an anaphylactic reaction appropriate treatment, such as adrenaline, should be administered without delay.
Most vaccinated animals may experience reactions to vaccination. These reactions are usually localised swelling (up to 14 cm in diameter, which resolves in less than 10 weeks) or induration at the injection site but may also include abscess (in up to 17% of animals) or other reaction in underlying tissues at the injection site.
Skin discolouration (which returns to normal as the local reaction resolves) and localised pain for 1-2 days post first vaccination may occur at the injection site. The local reactions do not affect the general health, demeanour, feeding or weight gain of the animals.
No information is available on the safety and efficacy from the concurrent use of this vaccine with any other. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
Do not mix with any other veterinary medicinal product.
Cattle: zero days.
Sheep: zero days.
In the case of accidental self-injection, encourage bleeding and wash the area immediately with water. If a local reaction develops, seek medical advice showing the package leaflet or the label to the physician.