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Date: Saturday, May 18, 2024 23:11

Description: Zoetis logo
Release 2.125
Cazitel Plus Tablets for Dogs
 
Species: Dogs
Therapeutic indication: Pharmaceuticals: Endoparasiticides: Anthelmintics for dogs
Active ingredient: Febantel, Praziquantel, Pyrantel Embonate
Product:Cazitel® Plus Tablets for Dogs
Product index: Cazitel Plus Tablets for Dogs
Incorporating:
Presentation
A pale yellow tablet with a cross breakline on one side, containing 50 mg praziquantel, 50 mg pyrantel (equivalent to 144 mg pyrantel embonate) and 150 mg febantel.
Uses
Indicated for the treatment of mixed infections by nematodes and cestodes of the following species in dogs:
Nematodes:
Ascarids: Toxocara canis, Toxascaris leonina (adult and late immature forms).
Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults).
Whipworms: Trichuris vulpis (adults).
Cestodes:
Tapeworms: Echinococcus species, (E. granulosus, E. multilocularis), Taenia species, (T. hydatigena, T. pisiformis, T. taeniformis), Dipylidium caninum (adult and immature forms).
Dosage and administration
Oral use.
The recommended dose rates are 15 mg/kg bodyweight febantel, 5 mg/kg pyrantel (equivalent to 14.4 mg/kg pyrantel embonate) and 5 mg/kg praziquantel. This is equivalent to 1 tablet per 10 kg bodyweight.
The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment.
To ensure a correct dosage, bodyweight should be determined as accurately as possible.
Dosage table (guide):
Bodyweight (kg)
Tablets
½ - 2
¼
3 - 5
½
6 - 10
1
11 - 15
1 ½
16 - 20
2
21 - 25
2 ½
26 - 30
3
31 - 35
3 ½
36 - 40
4
> 40
1 tablet per 10 kg
Underdosing could result in ineffective use and may favour resistance development.
The advice of a veterinarian should be sought regarding the need for and the frequency of repeat administration.
Contra-indications, warnings, etc
Do not use simultaneously with piperazine compounds as the anthelmintic effects of pyrantel and piperazine may be antagonized.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Fleas serve as intermediate hosts for one common type of tapeworm Dipylidium caninum. Tapeworm infestation is certain to reoccur unless control of intermediate hosts such as fleas, mice, etc. is undertaken.
Tapeworm infestation is unlikely in pups less than 6 weeks of age.
Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.
Very rare
(<1 animal / 10,000 animals treated, including isolated reports)
Digestive tract disorder (diarrhoea, emesis)
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system.
Concurrent use with other cholinergic compounds can lead to toxicity.
Teratogenic effects attributed to high doses of febantel have been reported in sheep and rats. No studies have been performed in dogs during early pregnancy.
Use of the veterinary medicinal product during pregnancy should be in accordance with a benefit risk assessment by the responsible veterinarian. It is recommended that the product is not used in dogs during the first 4 weeks of pregnancy. Do not exceed the stated dose when treating pregnant bitches.
Unnecessary use of antiparasitics or use deviating from the instructions given in the SPC may increase the resistance selection pressure and lead to reduced efficacy. The decision to use the product should be based on confirmation of the parasitic species and burden, or of the risk of infection based on its epidemiological features, for each individual animal.
In the absence of risk of co-infection with nematodes or cestodes, a narrow spectrum product should be used.
The possibility that other animals in the same household can be a source of reinfection with nematodes and cestodes should be considered, and these should be treated as necessary with an appropriate product.
User warnings
In case of accidental ingestion, seek medical advice and show the package leaflet or the label to the physician.
In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog’s food, should wash their hands afterwards.
Echinococcosis represents a hazard for humans. As echinococcosis is a notifiable disease to the World Organisation for Animal Health (OIE), specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.
Pharmaceutical precautions
This veterinary medicinal product does not require any special storage conditions.
Medicines should not be disposed of via wastewater. Any unused veterinary medicinal product or waster materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Discard any unused divided tablets immediately.
Keep out of the sight and reach of children.
For animal treatment only.
Legal category
Legal category: NFA-VPS
Packaging quantities
Cartons containing 104 tablets.
Further information
The combination of praziquantel, pyrantel embonate and febantel is well tolerated in dogs. In safety studies, a single dose of 5 times the recommended dose or greater gave rise to occasional vomiting.
Marketing Authorisation Holder (if different from distributor)
Chanelle Pharmaceuticals Manufacturing Ltd.
Marketing Authorisation Number
UK(GB): Vm 08749/5038
UK(NI): Vm 08749/3002
Significant changes
GTIN
GTIN description:104 tablets:
GTIN:05013457079920