75 – 100% of animals vaccinated with Covexin 10 may experience reactions to vaccination. These reactions are usually localised swelling or induration at the injection site but may also include mild hyperthermia, abscess or other reaction in the underlying tissues at the injection site.
Swelling at the injection site occurs in the majority of animals. This may reach up to a mean value of 6 cm in sheep and 15 cm diameter in cattle; occasionally reactions of up to 25 cm diameter may be seen in cattle. Most local reactions resolve in 3-6 weeks in sheep and less than 10 weeks in cattle, but may persist longer in a minority of animals. An abscess may develop in some animals. Vaccination may give rise to reactions in the underlying tissues at the injection site.
Skin discolouration at the injection site (which returns to normal as the local reaction resolved) may occur. Localised pain at the injection site for 1-2 days post vaccination may occur.
The local reactions do not affect the general health, demeanour, feeding or weight gain of the animals.
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
Do not mix with any other veterinary medicinal product.
In the event of an anaphylactic reaction appropriate treatment such as adrenaline should be administered without delay. Do not vaccinate sick or immunodeficient animals.
No side effects other than those described above have been seen when Covexin 10 has been used in sheep and cattle between 8 and 2 weeks prior to parturition. In the absence of specific data, no recommendation can be made for use of the vaccine during the first or second trimester of pregnancy.
Avoid stress in pregnant ewes and cows.
In case of accidental self-injection, seek medical advice immediately showing the package leaflet or the label to the physician.