Moxidectin is a member of the 3-ML anthelmintic class.
Clinical trials have shown that there are no signs of pain after injection and no irritation at the injection site.
CYDECTIN 1% Solution for Injection for Sheep has a wide margin of safety and symptoms of overdosage do not generally occur at less than 10 times the recommended dose. They are manifested as transient salivation, depression, drowsiness and ataxia 8 to 12 hours post-treatment. No treatment is generally necessary. The symptoms resolve in 24 to 48 hours. There is no specific antidote.
There are no known interactions with other animal health products used routinely in sheep such as mineral supplements, fluke or worm treatments, or clostridial vaccines.
PREVENTION AND TREATMENT OF SCAB
Prevention of scab
For routine prevention, all sheep in the flock must be injected once.
A single injection with CYDECTIN will protect against sheep scab for at least 28 days from the time of treatment. If sheep come in contact with infected animals after that time, infestation can occur.
All bought-in or returned animals should be treated and isolated for 12 days before mixing with the rest of the flock.
Ensure adequate fencing between neighbouring flocks.
It has been demonstrated that a single injection of all sheep in an area (with a double treatment of any clinically affected animals) is an effective alternative to routine autumn dipping to eradicate sheep scab.
Treatment of Scab Outbreaks
Inject all sheep in the affected flock or sub-flock, twice, 10 days apart.
The two injections must be given on different sides of the neck.
It is important to ensure that all in-contact sheep are treated.
Sheep scab mites can remain infective off the animal, on fences, posts etc. for at least 16 days. Since CYDECTIN protects for at least 28 days (i.e. longer than the time for which scab mites can remain infective off the animal), treated sheep can be immediately turned back onto the same pasture after dosing.
Since the effect of any injectable on scab mites is not immediate, contact between treated infected sheep and non-treated, non-infected sub-flocks must be avoided until at least 12 days after the last treatment.
TREATMENT AND CONTROL OF WORMS
Dosing guidelines
CYDECTIN is a member of the avermectin/milbemycin 3-ML class of anthelmintics. The advice of a veterinary surgeon should be sought in using CYDECTIN 1% Solution for Injection for Sheep in a dosing programme, to ensure correct diagnosis of the nematode infection present and to minimise the risk of developing resistance.
CYDECTIN gives optimal pasture protection against stomach worms (Ostertagia and Haemonchus) with an 8 week dosing interval - i.e. 5 week protection against stomach worm, plus a 3 week interval from any re-infection to the presence of eggs in the dung. More frequent dosing may be required for the treatment and control of intestinal worms (eg Trichostrongylus and Cooperia spp) due to a less persistent effect against these species of nematode. The following may be used as a guide:
Ewes: Treat at or around lambing to minimise the "spring rise", then again pre-tupping, when rams should be treated also.
After treatment, CYDECTIN continues to kill stomach worms picked up by the ewe for 5 weeks, thus substantially reducing pasture contamination. This "vacuum-cleaning" effect greatly reduces the worm challenge to lambs grazing the same pasture.
Lambs: The first dose should be given at around 4-6 weeks of age, with a second dose, if required 8 weeks later. For treatment and control of winter Trichostrongylosis (Black Scour) dosing may need to be repeated at more frequent intervals due to a less persistent effect against intestinal nematodes.
Nematodirus: For treatment and control of Nematodirus battus, use CYDECTIN 0.1% Oral Drench for sheep. Read package leaflet carefully before use.