Moxidectin is a member of the 3-ML anthelmintic class.
Reactions at the injection site have to be expected more frequently and severe depending on the injected volume.
Systemic signs of overdose are consistent with the mode of action of moxidectin. These signs are manifested as transient salivation, depression, drowsiness and ataxia 24 to 36 hours post-treatment. The systemic signs usually disappear within 36 to 72 hours without treatment. At doses >3 times the recommended dose divided on both ears, the systemic signs included recumbency, muscle tremor, ruminal tympany and dehydration which were resolved after treatment with fluids. The systemic signs can last for a few days to ten days. There is no specific antidote.
Can be used during pregnancy.
Immunity to nematodes depends on adequate exposure to infection. Although not normally the case, circumstances could occur in which anthelmintic control measures might increase the vulnerability of cattle to re-infection. Animals may be at risk towards the end of their first grazing season, particularly if the season is long, or in the following year if they move onto heavily contaminated pasture. In such instances, further control measures may be necessary.
The effects of GABA agonists are increased by moxidectin.