Orbenin L.A. is a suspension of cloxacillin as the sodium salt in a long acting base. It is presented in syringes containing 200 mg cloxacillin as Cloxacillin Sodium in 3 g of suspension.

For intramammary use in the treatment of clinical mastitis in lactating cows. The product is also indicated as an intramammary infusion in ewes at weaning for the treatment and prevention of mastitis.

Orbenin is active against Gram-positive organisms associated with mastitis. It is effective against Streptococcus agalactiae and other streptococcal species, penicillin-resistant and sensitive staphylococci and Trueperella pyogenes. Unlike natural penicillins, Orbenin is not destroyed by staphylococcal penicillinase. It is therefore active against penicillin-resistant staphylococci which are an important cause of mastitis.

The antibiotic is bactericidal at the concentrations produced in the udder and is non-irritant to the udder tissues.

In staphylococcal and certain forms of streptococcal mastitis, an adequate duration of treatment is important in achieving both clinical and bacteriological cures. Orbenin L.A. with its slow release is designed to meet these requirements.

A course of three infusions per infected quarter – one syringe given every 48 hours. Individual syringes must only be used once.

Clean and disinfect the teat end thoroughly with surgical spirit after milking. Insert nozzle into the teat and apply gentle and continuous pressure until the suspension is expressed. The treated quarter(s) may be milked out at the next normal milking time.

A single infusion should be made into each udder half at weaning.

It is important that a simple hygienic procedure is followed. One operator should turn up and hold each ewe whilst a second person carries out the infusion technique. Clean and disinfect each teat end thoroughly with surgical spirit. Appose the syringe nozzle to the teat orifice and apply gentle, continuous pressure to express the suspension in the udder. Actual cannulation of the teat orifice is neither necessary nor desirable. Use a fresh syringe for each udder half to avoid the possibility of cross contamination during infusion.

Cattle (milk): 96 hours.

Sheep (milk): not for use in ewes producing milk for human consumption.

Cattle and sheep (meat and offal): 7 days.

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.

Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.

Handle this product with great care to avoid exposure, taking all recommended precautions. Wash hands after use.

If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.

Do not store above 25°C. Store in a dry place.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.

Keep out of the sight and reach of children.

For animal treatment only.

Cartons of 12 syringes.