For intramammary use in the treatment of clinical mastitis in lactating cows. The product is also indicated as an intramammary infusion in ewes at weaning for the treatment and prevention of mastitis.
Orbenin is active against Gram-positive organisms associated with mastitis. It is effective against Streptococcus agalactiae and other streptococcal species, penicillin-resistant and sensitive staphylococci and Trueperella pyogenes. Unlike natural penicillins, Orbenin is not destroyed by staphylococcal penicillinase. It is therefore active against penicillin-resistant staphylococci which are an important cause of mastitis.
The antibiotic is bactericidal at the concentrations produced in the udder and is non-irritant to the udder tissues.
In staphylococcal and certain forms of streptococcal mastitis, an adequate duration of treatment is important in achieving both clinical and bacteriological cures. Orbenin L.A. with its slow release is designed to meet these requirements.