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Dosage and administration
For oral use.
Tablets can be administered with or without food.
The initial recommended dose is 3.25 mg/kg bodyweight, administered every second day (see dosing table for details).
The dose given should be based on veterinary assessments conducted weekly for the first six weeks and, thereafter, every six weeks. Duration of treatment depends on the response to treatment.
Treatment should continue in the case of stable disease, or partial or complete response, provided that the product is sufficiently well tolerated. In case of tumour progression, treatment is unlikely to be successful and should be reviewed.
See dosing table on the following page:
Bodyweight (kg)
Number of tablets
10 mg (blue)
15 mg (orange)
50 mg (red)
5.0* - 5.3
1
5.4 - 6.9
2
7.0 - 8.4
1
plus
1
8.5 - 10.0
2
10.1 - 11.5
2
plus
1
11.6 - 13.0
1
plus
2
13.1 - 14.6
3
14.7 - 16.1
1
16.2 - 17.6
1
plus
3
17.7 - 19.2
1
plus
1
19.3 - 20.7
1
plus
1
20.8 - 23.0
2
plus
1
23.1 - 26.9
2
plus
1
27.0 - 29.9
3
plus
1
30.0 - 32.3
2
32.4 - 34.6
1
plus
2
34.7 - 36.1
1
plus
2
36.2 - 38.4
2
plus
2
38.5 - 43.0
2
plus
2
43.1 - 47.6
3
47.7 - 49.9
1
plus
3
50.0 - 51.5
1
plus
3
51.6 - 53.8
2
plus
3
53.9 - 58.4
2
plus
3
58.5 - 63.0*
4
* The number of tablets required for dogs below 5.0 kg or above 63 kg bodyweight, should be calculated based on the 3.25 mg/kg dosage regime.
Dose adjustment/reduction
To manage adverse reactions, the dose may be reduced to 2.75 mg/kg bodyweight or further to 2.25 mg/kg bodyweight administered every second day or treatment can be discontinued for up to two weeks (see Dose Adjustment table on the following page).