Pathocef 250 mg Intramammary Suspension is a sterile white to off-white vegetable oil based suspension containing 250 mg cefoperazone (as the sodium salt) in each 10 ml of suspension.

Pathocef 250 mg Intramammary Suspension is indicated for the single dose treatment of clinical mastitis in lactating cows.

Cefoperazone is a third generation, semi-synthetic cephalosporin antibiotic with a broad spectrum of activity covering both Gram-positive and Gram-negative organisms. As a third generation cephalosporin, cefoperazone in vitro shows greater ability to withstand degradation by beta-lactamase enzymes than do members of the first and second generations.

Clinical mastitis caused by a wide range of organisms including the following pathogens has been shown to respond to treatment with Pathocef Intramammary Suspension: Streptococcus agalactiae; Streptococcus dysgalactiae; Streptococcus uberis; Staphylococcus aureus (including penicillinase producing strains); Escherichia coli; Trueperella pyogenes; Pseudomonas aeruginosa; Micrococcus spp.; Klebsiella spp.

The contents of one syringe should be infused into the infected quarter immediately after milking. Before infusion the teat should be thoroughly cleaned and disinfected.

Pathocef is contraindicated in animals which are known to have exhibited allergic reactions to cephalosporins or to have severe disturbance of kidney function.

There is a rare possibility of cross reaction with other beta-lactam antibiotics.

Cefoperazone is not compatible with aminoglycoside antibiotics such as streptomycin, neomycin and gentamycin. The simultaneous administration of possibly nephrotoxic drugs may prolong the elimination of cefoperazone.

Meat: 2 days.

Milk: 72 hours.

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.

Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions.

If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing, are more serious symptoms and require urgent medical attention.

Wash hands after use.

Do not store above 25°C. The syringe must only be used once.

Any unused veterinary medicinal product or waste materials from such veterinary medicinal products should be disposed of in accordance with local requirements.

For animal treatment only.

Keep out of the sight and reach of children.

Cartons of 4 syringes. 12 ml white opaque low density polyethylene syringe (containing 10 ml intramammary suspension) fitted with a protective cap of red low density polyethylene.

With other milking routines, the basis of the veterinary surgeon's advice should be that milk may be taken for human consumption only after the same period from the last treatment.