The veterinary medicinal product is a sterile product for intravenous administration.
General handling procedures
Prior to use, the product should be inspected visually for absence of particulate matter and discolouration and discarded if present.
Shake the vial gently but thoroughly before opening.
Dosage for induction by PropoFlo Plus
The induction dose is calculated according to bodyweight and may be administered to effect over a period of 10-40 seconds. The use of pre-anaesthetic drugs may markedly reduce propofol requirements. As with other sedative hypnotic agents, the amount of opioid, a‑2 agonist and/or benzodiazepine premedication will influence the response of the patient to an induction dose of the product.
Where animals have been premedicated with an a‑2 agonist such as medetomidine, the dose of propofol (as with any other intravenous anaesthetic agent) should be reduced by up to 85% (e.g. from 6.5 mg/kg for unpremedicated dogs to 1.0 mg/kg for dogs premedicated with an a‑2 agonist).
The average induction dose for dogs and cats, either unpremedicated or when premedicated with a non‑a‑2 agonist tranquilliser such as acepromazine, is given in the following table.
These doses are for guidance only; the actual dose should be based on the response of the particular animal.
| Dose mg/kg bodyweight | Dose volume ml/kg bodyweight |
DOGS | | |
Unpremedicated | 6.5 mg/kg | 0.65 ml/kg |
Premedicated | | |
- with non-α-2 agonist | 4.0 mg/kg | 0.40 ml/kg |
- with an α-2 agonist | 1.0 mg/kg | 0.10 ml/kg |
CATS | | |
Unpremedicated | 8.0 mg/kg | 0.80 ml/kg |
Premedicated | | |
- with non-α-2 agonist | 6.0 mg/kg | 0.60 ml/kg |
- with an α-2 agonist | 1.2 mg/kg | 0.12 ml/kg |
Dosage for maintenance by PropoFlo Plus
When anaesthesia is maintained by incremental injections, the dose rate will vary between animals. Administer incremental doses of the product to effect by giving small doses of around 0.1 ml/kg bodyweight (1.0 mg/kg bodyweight) of the induction dose when anaesthesia becomes too light. These doses may be repeated as often as required, allowing 20-30 seconds to assess the effect before further increments are given. Experience has shown that doses of approximately 1.25-2.5 mg (0.125-0.25 ml) per kg bodyweight sustain anaesthesia for periods of up to 5 minutes.
Continuous and prolonged exposure (greater than 30 minutes) may lead to slower recovery, particularly in cats.
Maintenance by inhalation agents
When inhalation agents are used to maintain general anaesthesia, experience indicates that it may be necessary to use a higher initial concentration of the inhalant anaesthetic than is usually required following induction with barbiturate agents such as thiopentone.