Reconstitution
Reconstitute aseptically by adding the contents of the solvent provided to the freeze-dried powder. Shake well to ensure contents are fully dissolved before use. Reconstituted solution should be used immediately.
Intramuscular or intravenous. Aseptic injection techniques should be practised. Where onset of activity is required within 30–180 minutes the intravenous route should be used; the required dose should be injected slowly over several minutes or given by intravenous infusion. For intravenous infusion, the initially prepared solution may be diluted with 5% dextrose in water, isotonic saline solution or 5% dextrose in isotonic saline. Do not mix with calcium solutions.
When treating overwhelming infections/toxicity or shock, the dose should be 20 to 30 mg/kg methylprednisolone/kg bodyweight (0.32–0.48 ml/kg); this may be repeated at 4–6 hours for 24–48 hours.
When treating spinal cord compression, the dose should be 30 mg/kg methylprednisolone/kg bodyweight (0.48 ml/kg) and should be given within the first two hours of trauma for maximum clinical benefit. The need for conjunctive surgery or other medicinal treatment should be considered according to individual clinical status.