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Dosage and administration
For intramuscular injection. Atipamezole (Antisedan) is quickly absorbed and is generally administered 15–60 minutes after the medetomidine or dexmedetomidine.
Dogs
The optimal dose of Antisedan, in micrograms per kilogram (mcg/kg), is five times that of the previous medetomidine dose or ten times that of the previous dexmedetomidine dose. The Antisedan dose in millilitres is the same as that of medetomidine 1mg/ml solution or dexmedetomidine 0.5mg/ml solution. The Antisedan dose in millilitres is one fifth (1/5) of the dose volume of dexmedetomidine 0.1mg/ml solution.
Where medetomidine (Domitor) or dexmedetomidine (Dexdomitor) has been used, with or without butorphanol, as a premedicant to thiopentone-halothane anaesthesia in dogs, or as a premedicant to propofol anaesthesia in dogs, Antisedan may be administered in the post-operative phase to reverse the effects of medetomidine or dexmedetomidine and hasten recovery. Antisedan in the post-operative phase rapidly causes arousal to full awareness and thus radically reduces the period of possible cardiovascular depression and hypothermia.
Cats
The optimal dose of Antisedan, in micrograms per kilogram (mcg/kg), is two-and-a-half times that of the previous medetomidine dose or five times that of the previous dexmedetomidine dose. The Antisedan dose in millilitres is half of the dose volume of medetomidine 1mg/ml solution or dexmedetomidine 0.5mg/ml solution and one tenth (1/10) of the dose volume of dexmedetomidine 0.1mg/ml solution.
The dose of Antisedan in micrograms per kilogram (mcg/kg) should not exceed four times that of the previously administered medetomidine or eight times that of dexmedetomidine.
When cats have been anaesthetised with medetomidine (Domitor) or dexmedetomidine (Dexdomitor), with or without butorphanol, and ketamine, Antisedan may be administered to reverse the effects of medetomidine or dexmedetomidine and so speed recovery from anaesthesia.