For use in dogs for the treatment of otitis externa of both bacterial and fungal origin – respectively due to bacteria sensitive to marbofloxacin, and fungi sensitive to clotrimazole. Use of the product should be based on susceptibility testing.
The preparation contains three active ingredients:
•Marbofloxacin: a synthetic anti-infectious bactericidal agent belonging to the fluoroquinolone family that acts by inhibiting DNA gyrase. It exhibits a very broad spectrum of activity against Gram-positive bacteria (in particular Staphylococcus intermedius) and against Gram-negative organisms (Pseudomonas aeruginosa, Escherichia Coli and Proteus mirabilis).
•Clotrimazole: an anti-fungal agent that belongs to the imidazole family and which acts by causing changes in membrane permeability, allowing intracellular compounds to leak from the cell and thus inhibiting cellular molecular synthesis. It exhibits a wide spectrum of activity and is aimed, in particular at Malassezia pachydermatis.
•Dexamethasone acetate: a synthetic glucocorticoid exhibiting anti-inflammatory and anti-pruritic activity.