Do not use in horses with severe liver parenchymal damage or kidney damage or known sulphonamide sensitivity, or horses with blood dyscrasias or cardiac arrhythmias. Do not exceed 7 days continuous treatment
The use of Trimediazine Plain in horses under 1 year old should be avoided.
In the rat and rabbit, trimethoprim/sulfadiazine combinations did not produce any foetal abnormalities at doses of up to 600mg/kg, although minor effects on skeletal development were seen below this level. As no studies have been conducted in horses, use on pregnant mares should be avoided.
When administered to lactating females, small amounts of trimethoprim and sulfadiazine are present in the maternal milk. Since no studies have been reported on the effects of Trimediazine Plain on the development of new born foals, it would be prudent not to feed very young foals with milk obtained from mares being treated.
As there is no specific antidote, in case of overdose, treatment should be symptomatic.
Withdrawal period
Meat: 6 months