Reconstitute the vaccine with 1 ml solvent or 1 ml (1 dose) of the inactivated vaccines (as specified in section 'Interaction with other medicinal products and other forms of interaction').
Subcutaneous use.
Avoid contamination of vaccine with traces of chemical sterilising agents. Do not use chemicals such as disinfectant or spirit to disinfect the skin prior to inoculation. Maternal antibodies can negatively interfere with the efficacy of a vaccine. Strict adherence to the vaccination programme is therefore recommended.
Vaccination programme
Primary vaccination course
A single injection should establish active immunity to canine distemper, infectious canine hepatitis and disease caused by canine parvovirus infection in dogs of 10 weeks of age or older.
Where earlier protection is required a first dose may be given to puppies from 6 weeks of age, but because maternally derived passive antibody can interfere with the response to vaccination a final dose at 10 weeks of age or older is generally recommended. For an optimal response to the parainfluenza component, animals should be vaccinated twice, 2–4 weeks apart with the final vaccination at 10 weeks of age or more.
If the initial primary course dose of Canigen DHPPi is delayed to 10 weeks of age or older, a single dose of Canigen Pi at 12 weeks of age or older should suffice to establish immunity for this component.
Booster vaccination
It is recommended that dogs be revaccinated with canine distemper virus, canine adenovirus and canine parvovirus every 3 years and against canine parainfluenza virus every year.
It was not possible to produce clinical signs of kennel cough by parainfluenza challenge in adult dogs and duration of immunity could not therefore be demonstrated, but an anamnestic response was seen in dogs given a booster one year after primary vaccination. Revaccination against parainfluenza is recommended prior to exposure to high risk environments (such as kennelling, showing or mixing with dogs of unknown vaccination history).