NOAH Compendium

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Date: Friday, September 25, 2020 16:06

Description: Virbac 2013
Release 3.23
Cephaguard DC 150 mg intramammary ointment
Species: Cattle
Therapeutic indication: Pharmaceuticals: Antimicrobials: Intramammaries: Dry cow
Active ingredient: Cefquinome
Product:Cephaguard DC 150 mg intramammary ointment
Product index: Cephaguard DC
Cattle - milk: See notes
Cattle - meat: 2 days
Withdrawal notes: 1 day after calving when the dry period is more than 5 weeks. 36 days after treatment where the dry period is 5 weeks or less.
For intramammary infusion in dry cows. Each syringe contains 150mg cefquinome (as sulphate) as active ingredient.
For the treatment of subclinical mastitis at drying off and the prevention of new bacterial infections of the udder during the dry period in the dairy cow caused by the following cefquinome-sensitive organisms: Streptococcus uberis, Streptococcus dysgalactiae, Streptococcus agalactiae, Staphylococcus aureus, coagulase negative staphylococci.
Dosage and administration
The contents of one syringe (150mg cefquinome) should be infused gently into the teat of each quarter, immediately after the last milking.
Before infusion, the udder should be milked out completely. The teat and its orifice should be thoroughly cleaned and disinfected with the cleaning towel provided. Care should be taken to avoid contamination of the nozzle. Insert gently either about 5mm or the whole length of the nozzle and infuse the contents of one syringe into each quarter. Disperse the product by gentle massage of the teat and udder. The syringe must only be used once.
Special precautions for use in animals
Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If it is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria
Do not use the cleaning towel on teats with lesions.
In case of erroneous use during lactation the milk should be discarded for 35 days.
Contra-indications, warnings, etc
Not to be administered to animals which are known to be hypersensitive to cephalosporin antibiotics or other ß-lactam antibiotics.
Not to be administered to cows with clinical mastitis.
Do not use the cleaning towel on teats with lesions.
Do not use in cows during lactation. In case of erroneous use during lactation the milk should be discarded for 35 days.
Withdrawal periods
Meat and offal: 2 days
Milk: 1 day after calving when the dry period is more than 5 weeks. 36 days after treatment where the dry period is 5 weeks or less.
Operator warnings
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross sensitivity to cephalosporin and vice versa. Allergic reactions to these substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended precautions.
3. If you develop symptoms following exposure, such as skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty in breathing are more serious symptoms and require urgent medical attention.
Wash hands after using the cleaning towels and wear protective gloves if skin irritation due to Isopropyl alcohol is known or suspected. For animal treatment only. Keep out of reach of children.
Pharmaceutical precautions
This medicinal product does not require any special storage conditions.
Disposal advice
Any unused product or waste materials should be disposed of in accordance with national requirements.
Legal category
Legal category: POM-V
Packaging quantities
Packs of 20 or 60 syringes.
Cleaning towels are included in each box.
Further information
In vitro activity has been demonstrated against common Gram-positive and Gram-negative bacteria including Escherichia coli, Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Arcanobacterium pyognes, Corynebacterium spp., Staphylococcus aureus, coagulase negative Staphylococci, Streptococcus dysgalactiae, Streptococcus agalactiae, Streptococcus uberis and Streptococcus bovis.
The efficacy of the product is only established against the pathogens mentioned above. Consequently, serious acute mastitis (potentially fatal) due to other pathogen species, mainly Pseudomonas aeruginosa, can occur after the drying off. Good hygienic practices should be thoroughly respected in order to reduce that risk; cows should be housed in a hygienic paddock far from the milking parlour and regularly checked several days after drying off.
The neutralizing effect of bacteriostatic acting pharmaceuticals (macrolides, sulfonamides and tetracyclines) on bactericidal effect of cefquinone has not been evaluated yet. Therefore there is no information about the safety and efficacy of this kind of association.
Marketing Authorisation Number
Significant changes
GTIN description:Cephaguard DC 15x4ml Inj
GTIN description:Cephaguard DC 4x4ml Inj