In vitro activity has been demonstrated against common Gram-positive and Gram-negative bacteria including Escherichia coli, Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Arcanobacterium pyognes, Corynebacterium spp., Staphylococcus aureus, coagulase negative Staphylococci, Streptococcus dysgalactiae, Streptococcus agalactiae, Streptococcus uberis and Streptococcus bovis.
The efficacy of the product is only established against the pathogens mentioned above. Consequently, serious acute mastitis (potentially fatal) due to other pathogen species, mainly Pseudomonas aeruginosa, can occur after the drying off. Good hygienic practices should be thoroughly respected in order to reduce that risk; cows should be housed in a hygienic paddock far from the milking parlour and regularly checked several days after drying off.
The neutralizing effect of bacteriostatic acting pharmaceuticals (macrolides, sulfonamides and tetracyclines) on bactericidal effect of cefquinone has not been evaluated yet. Therefore there is no information about the safety and efficacy of this kind of association.