Do not use in pregnant animals, for which induction of abortion or parturition is not intended. Do not use in animals with spastic diseases of the respiratory or gastrointestinal tract.
To reduce the risk of anaerobic infections, which might be related to the pharmacological properties of prostaglandins, care should be taken to avoid injection through contaminated areas of skin. Clean and disinfect injection sites thoroughly before application. Infection may occur if anaerobic bacteria penetrate the tissue at injection site.
When used for induction of parturition and dependent on the time of treatment relative to the date of conception, the incidence of retained placenta may be increased.
In very rare cases, anaphylactic-type reactions can be observed which might be life-threatening and require rapid medical care.
The product can be safely used during lactation.
Concurrent use of oxytocin and cloprostenol increases the effect on the uterus.
Therapeutic tolerance in cattle is broad. Overdoses of more than 10 times are generally well tolerated. Large overdoses may cause transient diarrhoea. No antidotes are available.
An overdose will not accelerate corpus luteum regression.
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Direct contact with skin or mucous membranes of the user should be avoided. Prostaglandins of the F2α type may be absorbed through the skin and may cause bronchospasm or miscarriage.
Care should be taken when handling the product to avoid self-injection or skin contact. Pregnant women, women of childbearing age, asthmatics and persons with other respiratory tract diseases should exercise caution when handling cloprostenol. Those persons should wear gloves during administration of this product. Accidental spillage on the skin should be washed immediately with soap and water.
In case of accidental self-injection, seek medical advice immediately and show the package insert or the label to the physician.
Meat and offal: 2 days
Milk: Zero days
For animal treatment only. Keep out of reach and sight of children.