NOAH Compendium

Printed from NOAH Compendium (http://www.noahcompendium.co.uk). (c) Copyright NOAH Compendium 2020. All Rights Reserved.
Date: Wednesday, November 25, 2020 10:26

Description: Virbac 2013
Release 2.18
Cyclix 250 microgram/ml solution for injection.
 
Species: Cattle
Therapeutic indication: Pharmaceuticals: Hormones and therapeutically related products: Prostaglandins/others
Active ingredient: Cloprostenol Sodium
Product:Cyclix 250 microgram/ml solution for injection
Product index: Cyclix 250 microgram/ml solution for injection.
Cattle - milk: Zero days
Cattle - meat: 2 days
Presentation
A solution for injection containing 263 micrograms per ml of cloprostenol sodium (corresponding to 250 micrograms cloprostenol) and 1 mg per ml of chlorocresol.
Uses
For the induction of luteolysis allowing resumption of oestrus and ovulation in cycling female cattle when used during dioestrus; synchronisation of oestrus (within 2 to 5 days) in groups of cycling females treated simultaneously; treatment of suboestrus and uterine disorders related to a functional or persistent corpus luteum (endometritis, pyometra); treatment of ovarian luteal cysts; induction of abortion until day 150 of pregnancy; expulsion of mummified foetuses; induction of parturition.
Dosage and administration
For all indications: 2 ml corresponding to 0.5 mg cloprostenol/animal, injected intramuscularly.
In order to synchronise oestrus in groups of female cattle, it is recommended that the product is administered on two occasions with a treatment interval of 11 days.
Contra-indications, warnings, etc
Do not use in pregnant animals, for which induction of abortion or parturition is not intended. Do not use in animals with spastic diseases of the respiratory or gastrointestinal tract.
To reduce the risk of anaerobic infections, which might be related to the pharmacological properties of prostaglandins, care should be taken to avoid injection through contaminated areas of skin. Clean and disinfect injection sites thoroughly before application. Infection may occur if anaerobic bacteria penetrate the tissue at injection site.
When used for induction of parturition and dependent on the time of treatment relative to the date of conception, the incidence of retained placenta may be increased.
In very rare cases, anaphylactic-type reactions can be observed which might be life-threatening and require rapid medical care.
The product can be safely used during lactation.
Concurrent use of oxytocin and cloprostenol increases the effect on the uterus.
Therapeutic tolerance in cattle is broad. Overdoses of more than 10 times are generally well tolerated. Large overdoses may cause transient diarrhoea. No antidotes are available.
An overdose will not accelerate corpus luteum regression.
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Operator warnings
Direct contact with skin or mucous membranes of the user should be avoided. Prostaglandins of the F2α type may be absorbed through the skin and may cause bronchospasm or miscarriage.
Care should be taken when handling the product to avoid self-injection or skin contact. Pregnant women, women of childbearing age, asthmatics and persons with other respiratory tract diseases should exercise caution when handling cloprostenol. Those persons should wear gloves during administration of this product. Accidental spillage on the skin should be washed immediately with soap and water.
In case of accidental self-injection, seek medical advice immediately and show the package insert or the label to the physician.
Withdrawal periods
Cattle:
Meat and offal: 2 days
Milk: Zero days
For animal treatment only. Keep out of reach and sight of children.
Pharmaceutical precautions
Keep the vial in the outer carton. Protect from light.
After first opening the product may be stored for 28 days.
Any unused product or waste material should be disposed of in accordance with national requirements.
Legal category
Legal category: POM-V
Packaging quantities
Cartons containing 20 ml or 50 ml glass bottles, closed with a halogenobutyl rubber stopper, teflon-coated. An aluminium crimp cap with an integral plastic tamper-evident cover is fixed over the rubber stopper.
Further information
Nil
Marketing Authorisation Number
Vm05653/4157
Significant changes
GTIN
GTIN description:Cyclix Bovine 20ml
GTIN:3597133045130
GTIN description:Cyclix Bovine 50ml
GTIN:3597133045147