Pharmacotherapeutic group: Prostaglandins
ATCvet code: QG02AD90
Pharmacodynamic properties
The Prostaglandin F2α analogue cloprostenol has luteolytic activity. Following its administration plasma progesterone falls to baseline levels. Progesterone concentrations start to decrease as early as 2 hours following injection. As a consequence, females with a sensitive CL (i.e. at least 5 days old) return to oestrus within 2-5 days of treatment and ovulate. The effect of cloprostenol on the smooth muscular system is similar to that of Prostaglandin F2α itself.
Pharmacokinetic particulars
Following intramuscular injection, cloprostenol is rapidly adsorbed and peak cloprostenol concentrations are generally reached within the first 15 minutes after injection. Blood cloprostenol concentrations steadily decrease with a mean half life of approx. 56 min.
Major incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.