Administration routes and dosage
Dogs:
Intramuscular or intravenous use.
For sedation the veterinary medicinal product should be administered at the rate of 750 µg medetomidine hydrochloride i.v. or 1000 µg medetomidine hydrochloride i.m. per square meter of body surface. Use the table below to determine the correct dosage on the basis of body weight: Maximal effect is obtained within 15 - 20 minutes. Clinical effect is dose-dependent, lasting from 30 - 180 minutes. The veterinary medicinal product dosages in ml and corresponding amount of medetomidine hydrochloride in μg /kg bw:
Dosing Guide: Medetor 1 mg/ml Solution for Injection for Dog & Cat |
Body weight (kg) | i.v. Injection (ml) | corresponding to (μg/kg) | i.m. injection (ml) | corresponding to (μg/kg) |
1 | 0.08 | 80.0 | 0.10 | 100.0 |
2 | 0.12 | 60.0 | 0.16 | 80.0 |
3 | 0.16 | 53.3 | 0.21 | 70.0 |
4 | 0.19 | 47.5 | 0.25 | 62.5 |
5 | 0.22 | 44.0 | 0.30 | 60.0 |
6 | 0.25 | 41.7 | 0.33 | 55.0 |
7 | 0.28 | 40.0 | 0.37 | 52.9 |
8 | 0.30 | 37.5 | 0.40 | 50.0 |
9 | 0.33 | 36.7 | 0.44 | 48.9 |
10 | 0.35 | 35.0 | 0.47 | 47.0 |
12 | 0.40 | 33.3 | 0.53 | 44.2 |
14 | 0.44 | 31.4 | 0.59 | 42.1 |
16 | 0.48 | 30.0 | 0.64 | 40.0 |
18 | 0.52 | 28.9 | 0.69 | 38.3 |
20 | 0.56 | 28.0 | 0.74 | 37.0 |
25 | 0.65 | 26.0 | 0.86 | 34.4 |
30 | 0.73 | 24.3 | 0.98 | 32.7 |
35 | 0.81 | 23.1 | 1.08 | 30.9 |
40 | 0.89 | 22.2 | 1.18 | 29.5 |
50 | 1.03 | 20.6 | 1.37 | 27.4 |
60 | 1.16 | 19.3 | 1.55 | 25.8 |
70 | 1.29 | 18.4 | 1.72 | 24.6 |
80 | 1.41 | 17.6 | 1.88 | 23.5 |
90 | 1.52 | 16.9 | 2.03 | 22.6 |
100 | 1.63 | 16.3 | 2.18 | 21.8 |
For premedication:
10 - 40 µg medetomidine hydrochloride per kg body weight, corresponding to 0.1 - 0.4 ml per 10 kg body weight. The exact dose depends on the combination of drugs used and the dosage(s) of the other drug(s). The dose should furthermore be adjusted to the type of surgery, length of procedure and patient temperament and weight. Premedication with medetomidine will significantly reduce the dosage of the induction agent required and will reduce volatile anaesthetic requirements for maintenance anaesthesia. All anaesthetic agents used for induction or maintenance of anaesthesia should be administered to effect. Before using any combinations, product literature for the other veterinary medicinal products should be observed.
Cats:
Intramuscular use.
For moderate-deep sedation and restraint of cats the veterinary medicinal product should be administered at a dosage of 50 - 150 µg medetomidine hydrochloride /kg bw (corresp. to 0.05 - 0.15 ml veterinary medicinal product / kg bw).
For anaesthesia the veterinary medicinal product should be administered at a dosage of 80 µg medetomidine hydrochloride / kg bw (corresp. to 0.08 ml veterinary medicinal product / kg bw) and 2.5 to 7.5 mg ketamine / kg bw. Using this dosage anaesthesia occurs within 3 - 4 minutes and is apparent for 20 - 50 minutes. For longer lasting procedures administration has to be repeated by using ½ of the initial dose (i.e. 40 µg medetomidine hydrochloride (corresp. to 0.04 ml veterinary medicinal product / kg bw) and 2.5 - 3.75 mg ketamine / kg bw) or 3.0 mg ketamine / kg bw alone. Alternatively, for longer lasting procedures anaesthesia may be extended by use of the inhalation agents isoflurane or halothane, with oxygen or oxygen/nitrous oxide.