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Date: Thursday, December 2, 2021 15:27

Description: Virbac 2013
Release 2.17
Milpro film-coated tablets for Cats and Kittens
 
Species: Cats
Therapeutic indication: Pharmaceuticals: Endoparasiticides: Anthelmintics for cats, Tapeworm products
Active ingredient: Milbemycin Oxime, Praziquantel
Product:Milpro film-coated tablets for cats and kittens
Product index: Milpro film-coated tablets for cats and kittens
Qualitative and quantitative composition
Milpro 4mg/10mg for small cats and kittens: Each tablet contains as active substances: Milbemycin oxime 4mg and Praziquantel 10mg
Milpro 16mg/40mg for cats: Each tablet contains as active substances: Milbemycin oxime 16mg and Praziquantel 40mg
Pharmaceutical form
Oval shaped, film coated, meat flavoured tablets with a score on both sides. Tablets can be divided into halves.
Milpro 4mg/10mg for small cats and kittens are dark brown.
Milpro 16mg/40mg for cats are red to pink.
Clinical particulars
Target species
Cats
Indications for use
In cats: treatment of mixed infections by immature and adult cestodes (tapeworms) and adult nematodes (roundworms) of the following species:
Cestodes:
Echinococcus multilocularis
Dipylidium caninum,
Taenia spp.,
Nematodes:
Ancylostoma tubaeforme,
Toxocara cati
Prevention of heartworm disease (Dirofilaria immitis), if concomitant treatment against cestodes is indicated.
Contra-indications
Milpro for small cats and kittens: Do not use in kittens of less than 6 weeks of age and/or weighing less than 0.5 kg.
Milpro for cats: Do not use in cats weighing less than 2kg
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
It is recommended to treat all the animals living in the same household concomitantly.
In order to develop an effective worm control programme local epidemiological information and the living conditions of the cat should be taken into account and therefore it is recommended to seek professional advice.
Parasite resistance to any particular class of anthelmintic may develop following frequent, repeated use of an anthelmintic of that class.
When D. caninum infection is present, concomitant treatment against intermediate hosts, such as fleas and lice, should be considered to prevent re-infection.
Special precautions for use
Special precautions for use in animals
No studies have been performed with severely debilitated cats or individuals with seriously compromised kidney or liver function. The product is not recommended for such animals or only according to a benefit/risk assessment by the responsible veterinarian.
Studies have shown that treatment of dogs with a high number of circulating microfilariae can sometimes lead to the appearance of hypersensitivity reactions, such as pale mucous membranes, vomiting, trembling, laboured breathing or excessive salivation. These reactions are associated with the release of proteins from dead or dying microfilariae and are not a direct toxic effect of the product. The use in dogs suffering from microfilaremia is thus not recommended. In the absence of data on cats with microfilaraemia, its use should be according to a benefit risk assessment by the attending veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after use.
In the event of accidental ingestion of the tablets, particularly by a child, seek medical advice immediately and show the package leaflet or the label to the doctor.
Adverse reactions
In very rare occasions, especially in young cats, systemic signs (such as lethargy), neurological signs (such as ataxia and muscle tremors) and/or gastrointestinal signs (such as emesis and diarrhoea) may be observed after administration of the veterinary medicinal product.
Use during pregnancy, lactation or lay
In a study, this combination of active substances was demonstrated to be well tolerated in breeding bitches, including during pregnancy and lactation. As a specific study with this product has not been performed, use during pregnancy and lactation only according to a benefit/risk assessment by the responsible veterinarian
Interactions
The concurrent use of the combination praziquantel/milbemycin oxime with selamectin is well tolerated. No interactions were observed when the recommended dose of the macrocyclic lactone selamectin was administered during treatment with the combination at the recommended dose. In the absence of further studies, caution should be taken in the case of concurrent use of the product and other macrocyclic lactones. Also no such studies have been performed with reproducing animals
Amounts to be administered and administration route
Oral use.
As per good veterinary practice, animals should be weighed to ensure accurate dosing.
Minimum recommended dose rate: 2 mg of milbemycin oxime and 5 mg of praziquantel per kg are given orally as a single dose.
The product should be administered with or after some food.
The product is a small size tablet.
To aid with administration, the product has been coated with a meat flavour.
The tablets can be divided into halves.
Depending on the bodyweight of the cat, the practical dosing is as follows:
Weight
Tablets
Milpro 4mg/10mg for small cats and kittens
0.5 - 1 kg
½ tablet
>1 - 2 kg
1 tablet
Milpro 16mg/40mg for cats
2 - 4 kg
½ tablet
>4 - 8 kg
1 tablet
>8 - 12 kg
1 ½ tablets
In cases when heartworm disease prevention is used and at the same time treatment against tapeworm is required, the product can replace the monovalent product for the monthly prevention of heartworm disease.
Overdose
In a study conducted with the product administered at 1X, 3X and 5X the therapeutic dose, and for a duration which exceed the therapeutic indication, i.e. 3 times at 15 day-intervals, signs uncommonly reported at the recommended dose (see section 4.6) have been observed at 5-fold the therapeutic dose after the second and third treatments. These signs disappeared spontaneously within a day.
Withdrawal periods
Not applicable
Pharmacological particulars
Pharmacodynamic properties
Milbemycin oxime belongs to the group of macrocyclic lactones, isolated from the fermentation of Streptomyces hygroscopicus var. aureolacrimosus. It is active against mites, against larval and adult stages of nematodes as well as against larvae of Dirofilaria immitis. The activity of milbemycin is related to its action on invertebrate neurotransmission: Milbemycin oxime, like avermectins and other milbemycins, increases nematode and insect membrane permeability to chloride ions via glutamate-gated chloride ion channels (related to vertebrate GABAA and glycine receptors). This leads to hyperpolarisation of the neuromuscular membrane and flaccid paralysis and death of the parasite.
Praziquantel is an acylated pyrazino-isoquinoline derivative. Praziquantel is active against cestodes and trematodes. It modifies the permeability for calcium (influx of Ca2+) in the membranes of the parasite inducing an imbalance in the membrane structures, leading to membrane depolarisation and almost instantaneous contraction of the musculature (tetany), rapid vacuolization of the syncytial tegument and subsequent tegumental disintegration (blebbing), resulting in easier expulsion from the gastrointestinal tract or death of the parasite.
Pharmacokinetic properties
In the cat, praziquantel reaches peak plasma concentrations within 1-4 hours after oral administration. The half life of elimination is around 3 hours. In the dog, there is rapid hepatic biotransformation, principally to monohydroxylated derivatives. The principal route of elimination in the dog is renal.
After oral administration in the cat, milbemycin oxime reaches peak plasma concentrations within 2-4 hours. The half life of elimination is around 32 to 48 hours.
In the rat, metabolism appears to be complete although slow, since unchanged milbemycin oxime has not been found in urine or feces. Main metabolites in the rat are monohydroxylated derivatives, attributable to hepatic biotransformation. In addition to relatively high liver concentrations, there is some concentration in fat, reflecting its lipophilicity
Pharmaceutical particulars
Excipients
Core:
Microcrystalline cellulose
Croscarmellose sodium
Magnesium stearate
Povidone
Silica hydrophobic colloidal
Coat:
Natural Poultry liver flavour
Hypromellose
Microcrystalline cellulose
Macrogol stearate
Iron oxide (E172) (Milpro for small cats and kittens)
Allura Red AC (E129) (Milpro for cats)
Titanium Dioxide (E171)
Major incompatibilities
Not applicable
Shelf life
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening the immediate packaging: 6 months.
Special precautions for storage
This veterinary medicinal product does not require any special temperature storage conditions.
Half tablets should be stored in the original blister and be used for the next administration.
Keep the blister in the outer carton.
Immediate packaging
Aluminium/ Aluminium blister pack (Oriented polyamide/Aluminium/Polyvinyl chloride sealed to Aluminium film).
Available pack sizes:
1 box of 2 tablets containing 1 blister of 2 tablets (divisible per tablet)
1 box of 4 tablets containing 2 blisters of 2 tablets (divisible per tablet)
1 box of 24 tablets containing 12 blisters of 2 tablets (divisible per tablet)
1 box of 48 tablets containing 24 blisters of 2 tablets (divisible per tablet) - Milpro for cats only
Not all pack sizes may be marketed
Disposal
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
The product should not enter water courses as this may be dangerous for fish and other aquatic organisms
Marketing Authorisation Holder (if different from distributor)
Virbac
1ère avenue – 2065m – L.I.D.
06516 Carros
FRANCE
Marketing Authorisation Number
Milpro 4mg/10mg tabs for small cats and kittens Vm 05653/4183
Milpro 16mg/40mg tabs for cats Vm 05653/4184
Significant changes
Date of the first authorisation or date of renewal
August 2014
Date of revision of the text
Any other information
Nil
Legal category
Legal category: POM-V
GTIN
GTIN description:Milpro film-coated tablets for small cats and kittens 24 pack
GTIN:03597133067194
GTIN description:Milpro film-coated tablets for cats 4 pack
GTIN:03597133067170
GTIN description:Milpro film-coated tablets for cats 48 pack
GTIN:03597133067187