Pharmacodynamic properties
Propofol is a substituted phenol which, when given by intravenous injection, is a short-acting anaesthetic with a rapid rate of onset. Recovery from anaesthesia is usually rapid.
Pharmacokinetic properties
After a single bolus administration, blood level profiles are characterised by a rapid distribution phase and a rapid elimination phase. No accumulation of propofol in blood has been observed after multiple daily dosing.
Propofol is metabolised by the liver. Urinary excretion is the major route of elimination of metabolites from the body.