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Date: Wednesday, May 29, 2024 18:42

Description: 2015-Elanco-logo
Telephone: 01256 353131 (24 hr response) Veterinary Technical Services
Release 9.26
Species: Rabbits
Therapeutic indication: Pharmaceuticals: Ectoparasiticides: For rabbits
Active ingredient: Cyromazine
Product index: Rearguard
Withdrawal notes: Not to be used in animals intended for human consumption
Qualitative and quantitative composition
Active ingredient% w/v
Cyromazine 6.00
Other ingredients
Methyl parahydroxybenzoate 0.081
Ethyl parahydroxybenzoate 0.017
Propyl parahydroxybenzoate 0.016
For a full list of excipients, see Pharmaceutical particulars.
Pharmaceutical form
Cutaneous solution
Clear, pale yellow solution
Clinical particulars
Target species
Indications for use, specifying the target species
For the prevention of blowfly strike (Lucilia sericata) in domestic rabbits for up to 10 weeks after dosing
Not to be used on rabbits less than 10 weeks of age. Do not apply to broken skin.
Special warnings for each target species
If the rabbit is continually attractive to flies, this may be due to an underlying disease e.g. diarrhoea or incontinence, or a lack of hygiene within it’s housing. In such cases further advice should be sought from your veterinary surgeon.
Special precautions for use
Special precautions for use in animals
Care should be taken in the treatment of old, sick or debilitated rabbits.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands and exposed skin after use.
Wash splashes from skin and eyes immediately.
Do not smoke whilst using the product.
Adverse reactions (frequency and seriousness)
Treated rabbits may show a transient reduction in appetite in the 24-48 hours following treatment.
Use during pregnancy, lactation or lay
Not to be used in pregnant or breeding females.
Interaction with other medicinal products and other forms of interaction
None known
Amounts to be administered and administration route
Rearguard comes supplied ready-to-use in a bottle with built-in applicator sponge. Gently depress the sponge to break the valve before applying.
Apply the product using the sponge applicator, ensuring that the rabbit’s fur is thoroughly wetted with the solution from the middle of the back to the tip of the tail. Special attention should be paid to the areas under the tail and between the back legs. Do not allow the product to run off the animal.
Rabbits should be first treated in early summer before any flies are seen. Rearguard will not kill adult maggots but works by preventing any eggs laid by flies developing.
Rabbits should be treated at 8-10 week intervals under conditions of repeated blowfly challenge. Bathing or washing the rabbit after application may result in a reduction of efficacy.
In cases of existing flystrike, adult maggots should be removed by mechanical means and appropriate supportive treatment given. Rearguard should then be applied to the fur to prevent development of new larvae and re-strike.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Not applicable.
Withdrawal period(s)
Not to be used on rabbits intended for human consumption.
Pharmacological particulars
Pharmacotherapeutic group: Antiparasitic products, insecticides and repellents
Other ectoparasiticides for topical use
ATC Vet Code: QP53AX
Pharmacodynamic properties
Cyromazine is an insect growth regulator. It is not pharmacologically active in mammals.
Pharmacokinetic particulars
Dermal absorption rate a maximum of 10% of dose over 8 hours. Cyromazine rapidly excreted in mammals and birds.
Pharmaceutical particulars
List of excipients
Methyl parahydroxybenzoate
Ethyl parahydroxybenzoate
Propyl parahydroxybenzoate
Lactic acid edible 80
Acetic acid glacial
Propylene glycol
Macrogol cetostearyl ether
Silicone emulsion
Water de-ionised
None known
Shelf life
Shelf life of veterinary medicinal product as packaged for sale: 3 years
Special precautions for storage
Do not store above 25°C.
Protect from frost.
Protect from direct sunlight.
Shake the container before use.
Store in tightly closed original container.
Store away from food and drink.
Nature and composition of immediate packaging
A white pigmented HDPE bottle with a blue LDPE valve and white LDPE sponge applicator, closed with a white LDPE push cap containing 25ml of product.
Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from the use of the veterinary medicinal product should be disposed of in accordance with local requirements
Marketing Authorisation Holder (if different from distributor)
Marketing Authorisation Number
Vm 00879/4009
Significant changes
Date of the first authorisation or date of renewal
20 June 2002
Date of revision of the text
December 2015
Any other information
Legal category
Legal category: NFA-VPS