The veterinary medicinal product is an insecticidal and acaricidal solution for spot-on use, containing pyriprole as active substance. Pyriprole is an insecticide and acaricide belonging to the phenylpyrazole class. It acts by interacting with ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. This results in uncontrolled activity of the central nervous system and death of fleas and ticks. In dogs, adverse reactions are associated with neurological signs caused by metabolites of the active substance. Parasites are killed through contact rather than by systemic exposure. Pyriprole kills fleas within 24 hours and ticks (Ixodes ricinus, Rhipicephalus sanguineus, Dermacentor reticulatus, Ixodes scapularis, Dermacentor variabilis, Amblyomma americanum) within 48 hours post-exposure.

Adult fleas are killed before they lay eggs for a minimum of 4 weeks after treatment. Since the veterinary medicinal product completely eliminates egg production, it breaks the flea life cycle.

In dogs, after administration to the skin pyriprole is slowly absorbed by skin, leading to a systemic exposure by its two main metabolites. Following administration to the skin pyriprole is rapidly distributed in the hair coat of dogs within one day after application. It can be found in the hair coat throughout the treatment interval.

Pyriprole may be harmful to aquatic organisms.