Meat and offal: 2 days

The safety of Aivlosin® during pregnancy and lactation has not been established in pigs. Use only in accordance with risk/benefit assessment by the responsible veterinarian. Studies in laboratory animals have not produced any evidence of teratogenicity. Maternal toxicity in rodents has been observed at doses of 400 mg tylvalosin per kg bodyweight and above. In mice, a slight reduction in the foetal bodyweight was seen at doses causing maternal toxicity.

Acute cases and severely diseased pigs with reduced foor or water intake should be treated with a suitable injectable product.

Generally, stains of B.hyodysenteriae have higher minimal inhibitory concentration (MIC) values in cases of resistance against other macrolides, such as tylosin. The clinical relevance of this reduced susceptibility is not fully explored. Cross-resistance between tylvalosin and other macrolides cannot be excluded.

Good management and hygiene practises should be followed to reduce the risk of re-infection.

It is sound clinical practise to base treatment on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of target bacteria.

Use of the veterinary medicinal product deviating from the instructions in the SPC may increase the risk of development and selection of resistant bacteria and decrease the effectiveness of treatment with other macrolides due to potential for cross - resistance.

Tylvalosin has been shown to cause hypersensitivity (allergic) reactions in laboratory animals; therefore people with known hypersensitivity to tylvalosin tartrate should avoid contact with this product.

When mixing the veterinary medicinal product and handling the medicated feed, direct contact with eyes, skin and mucous membranes should be avoided. Personal protective equipment should be worn when mixing the veterinary medicinal product or handling the medicated feed: overalls, impervious gloves and either a disposable half-mask respirator conforming to European Standard EN 149 or a non-disposable respirator conforming to European Standard EN 140, with a filter to EN 143. Wash contaminated skin.

In case of accidental ingestion seek medical advice immediately and show the label to the physician.

In the absence of compatibility studies, this veterinary medical product must not be mixed with other veterinary medicinal products.