Target Species
Cattle (cows).
Indications for use
The veterinary medicinal product is indicated for the treatment of subacute and chronic endometritis in cows (at least 14 days after parturition) caused by bacteria sensitive to cefapirin.
Contraindications
Do not use in cases of hypersensitivity to cephalosporins or other beta-lactam antibiotics.
Special warnings for each target species
None
Special precautions for use
Use of the product should be based on identification and susceptibility testing of the target pathogen(s). If this is not possible, therapy should be based on epidemiological information and knowledge of susceptibility of the target pathogens at farm level, or at local/regional level.
Use of the product should be in accordance with official, national and regional antimicrobial policies.
An antibiotic with a lower risk of antimicrobial resistance selection (lower AMEG category) should be used for first line treatment where susceptibility testing suggests the likely efficacy of this approach.
Operator warnings
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross sensitivity to cephalosporins and vice versa. Allergic reactions to these substances are occasionally serious.
People with known hypersensitivity to penicillins and cephalosporins should avoid contact with the veterinary medicinal product.
Do not handle this veterinary medicinal product if you know you are sensitised or if you have been advised not to work with such preparations.
Handle this veterinary medicinal product with great care to avoid exposure, taking all recommended precautions.
If you develop symptoms following exposure, such as a skin rash, seek medical advice immediately and show the package leaflet or the label to the physician. Swelling of the face, lips or eyes or difficulty breathing are more serious symptoms and require urgent medical attention.
Accidental spillage on the skin should be washed off immediately with soap and water.
Wash hands after use.
Adverse Reactions
Cattle (cows):
Very rare (<1 animal / 10,000 animals treated, including isolated reports): | Hypersensitivity reaction |
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Use during pregnancy or lactation
The veterinary medicinal product is not indicated for use during pregnancy but can be used during lactation.
Interactions
Not to be administered concurrently with other intra-uterine antibiotic preparations.
Amounts to be administered and administration route
Intrauterine use.
The contents of one yringe should be introduced into the lumen of the uterus using the disposable catheter provided as follows:
1. Shake the syringe before use.
2. Fix the syringe to the catheter.
3. Hold the cervix of the uterus with one gloved hand introduced into the rectum
4. Introduce the catheter through the cervix into the lumen of the uterus, by gentle oscillating movements of the cervix.
5. Inject the contents of the syringe.
Depending on the response, a second treatment 7-14 days later may be required in some cases if clinical signs persist.
In animals that have been inseminated, the veterinary medicinal product may be used at one day after insemination. In cases of pyometra, pre-treatment with prostaglandin is recommended in order to induce luteolysis and remove debris from the uterine cavity.
Overdose
The veterinary medicinal product is supplied as a single dose syringe, therefore overdose is unlikely to occur.
Withdrawal periods
Meat - 1 day.
Milk - Zero hours.