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Clinical particulars
Target species
Dogs.
Indications for use
For the treatment of mixed infections with the following gastrointestinal tapeworms and roundworms in dogs and puppies. Roundworms (nematodes) Ascarids: Toxocara canis, Toxascaris leonina (adult and late immature forms). Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults). Whipworms: Trichuris vulpis (adults). Tapeworms (cestodes): Echinococcus species (E. granulosus, E. multilocularis), Taenia species (T. hydatigena, T. pisiformis, T. taeniformis), Dipylidium caninum (adult and immature forms).
Contraindications
Do not use simultaneously with piperazine compounds as piperazine may block the action of pyrantel embonate contained in this product. Other worming products may contain piperazine. Do not use simultaneously with other deworming products without veterinary advice. Do not use in animals with a known sensitivity to the active ingredients or to any of the excipients.
Special warnings for each target species
Fleas serve as intermediate hosts for one common type of tapeworm – Dipylidium caninum. Tapeworm infestation is certain to reoccur unless control of intermediate hosts such as fleas, mice, etc. is undertaken. Tapeworm infestation is unlikely in puppies less than 6 weeks of age. Development of parasite resistance to anthelmintics of a certain class can occur after frequent and repeated use of an anthelmintic from that class.
Special precautions to be taken by the person administering the veterinary medicinal product
In case of accidental ingestion, seek medical advice and show the package leaflet or carton to the physician. In the interests of good hygiene, persons administering the tablets directly to the dog, or by adding them to the dog’s food, should wash their hands afterwards. Echinococcosis represents a hazard for humans. As echinococcosis is a notifiable disease to the World Organisation for Animal Health (OIE), specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.
Adverse reactions
In very rare cases (1 animal in 10,000, including isolated reports), gastrointestinal disorders (diarrhoea, emesis) have been observed.
Use during pregnancy and lactation
Consult a veterinary surgeon before treating pregnant animals. Teratogenic effects attributed to high doses of febantel have been reported in sheep and rats. No studies have been performed in dogs during early pregnancy. Use of the product during pregnancy should be in accordance with a benefit risk assessment by the responsible veterinary surgeon. It is recommended that the product is not used in dogs during the first 4 weeks of pregnancy. The product may be used in lactating bitches from two weeks after giving birth.
Interaction with other medicinal products
Do not use simultaneously with piperazine compounds. Concurrent use with other cholinergic compounds can lead to toxicity.
Dosage and method of administration
The recommended dose rate is 1 tablet per 10kg bodyweight as a single dose. It is important to follow the treatment recommendations presented here. Do not deviate from these recommendations without the advice of your veterinary surgeon.
Bodyweight
Number of tablets
≥3–5kg
½
≥5–10kg
1
≥10–15kg
1 ½
≥15–20kg
2
≥20–25kg
2 ½
≥25–30kg
3
≥30–35kg
3 ½
≥35–40kg
4
For oral administration only. The tablets can be given directly to the dog or disguised in food. No starvation is needed before or after treatment. Not for use in dogs weighing less than 3kg. Puppies should be treated at 2 weeks of age and every 2 weeks until 12 weeks of age. Thereafter they should be treated at 3 month intervals. It is advisable to treat the bitch at the same time as the puppies. For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every two weeks until weaning. For routine worm control adult dogs should be treated every 3 months. For routine treatment a single dose is recommended. In case of suspected heavy roundworm infestation, please contact your veterinary surgeon for diagnosis and treatment recommendations.
Overdose
The combination of praziquantel, pyrantel embonate and febantel is well tolerated in dogs. In safety studies, a single dose of 5 times the recommended dose or greater gave rise to occasional vomiting.