Anthelmin Plus Flavour Tablets for Dogs are a round, yellow tablet with visible darker spots and bevelled edges with cross line on one side and plain on other side. The tablets can be divided into equal halves or equal quarters. The tablets contain Praziquantel 50mg, Pyrantel embonate 144mg and Febantel 150mg with excipients.

Anthelmin Plus XL Tablets for Dogs are slightly greenish yellow, oval, biconvex tablets with bevelled edges and scored on both sides. The tablets can be divided into equal halves. The tablets contain Praziquantel 175mg, Pyrantel embonate 504mg and Febantel 525mg with excipients.

Anthelmin Plus Flavour & Anthelmin Plus XL - For the treatment of mixed infestations with the following roundworms and tapeworms in adult dogs and puppies:

Nematodes - Ascarids: Toxocara canis, Toxascaris leonina (late immature forms and mature forms) Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults)

Cestodes - Tapeworms: Taenia spp., Dipylidium caninum

Dosage:

Anthelmin Plus Flavour – For treatment of dogs administer 1 tablet per 10kg bodyweight (15 mg/kg bodyweight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel). This is equivalent to 1 tablet per 10 kg bodyweight. Tablets may be halved/quartered to allow accuracy of dosing.

Anthelmin Plus XL 1 tablet per 35 kg bodyweight. Tablets may be halved to allow accuracy of dosing.

The tablet(s) can be given directly to the dog or disguised in food. No restriction of access to food is required either before or after administration of the product. To ensure administration of a correct dose, body weight should be determined as accurately as possible. Puppies may be wormed with this product from 2 weeks of age and every 2 weeks until 12 weeks of age. Thereafter they should be treated at 3 monthly intervals until 6 months of age.

For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every 2 weeks until weaning. For adult dogs, a single dose should be used. The advice of a veterinarian should be sought regarding the need for and frequency of repeat treatment. In the event of a heavy roundworm infestation, a repeat dose should be given after 14 days.

Anthelmin Plus Flavour and Anthelmin Plus XL - Consult a veterinary surgeon before treating pregnant animals for roundworms.

Do not use the product in the first two thirds of pregnancy. The product may be used during lactation.

Any part-used tablets should be discarded.

In the interests of good hygiene, persons administering the tablet directly to a dog or by adding it to the dog's food, should wash their hands afterwards.

In case of accidental ingestion, seek medical advice and show the package leaflet to the physician.

Benzimidazoles possess wide safety margin. Pyrantel is not absorbed systematically to any extent. Praziquantel also has a wide safety margin, of up to five times the recommended dose.

Mild and transient digestive tract disorders such as hypersalivation and/or vomiting and mild and transient neurological disorders such as ataxia may occur in extremely rare cases.

Do not use in cases of known hypersensitivity to the active substances or to any of the excipients.

Do not exceed the stated dosage when treating pregnant bitches.

Not for use in dogs younger than 2 weeks of age and/or weighing less than 2 kg.

Anthelmin Plus XL is not recommended for use in dogs under 17.5 kg bodyweight.

Veterinary medicinal product is well tolerated in dogs. In safety studies of up to five times the recommended dose gave rise to occasional vomiting.

Do not combine with piperazine as the anthelmintic effects of pyrantel and piperazine (used in many worming products for dogs) may be antagonized.Concurrent use with other cholinergic compounds can lead to toxicity.

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

Store in the original packaging in order to protect from light and moisture.

Shelf-life of unopened package: 3 years.

Anthelmin Plus XL - Any part-used tablets should be discarded.

In the interests of good hygiene, persons administering the tablet directly to a dog or by adding it to the dog's food, should wash their hands afterwards.

In case of accidental ingestion, seek medical advice and show the package leaflet to the physician.

Anthelmin Plus Flavour - 4 and 100 tablet packs

Anthelmin Plus XL - 12 tablet pack

KRKA, d.d., Novo mesto

Šmarješka cesta 6

8501 Novo mesto

Slovenia

Pharmacotherapeutic group: Anthelmintics, Benzimidazoles and related substances

ATCvet code: QP52AC55

Benzimidazoles possess wide safety margin. Pyrantel is not absorbed systematically to any extent. Praziquantel also has a wide safety margin, of up to five times the recommended dose.

The product contains anthelmintics active against roundworms and tapeworms. The product contains three active substances: febantel, pyrantel embonate (pamoate) and praziquantel, a partially hydrogenated pyrazino-isoquinoline derivative used widely as an anthelmintic for both human and veterinary use. Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow removal from the gastro-intestinal (GI) system by peristalsis.

With the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerization. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2 – 3 days later.

Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.

In this fixed combination product pyrantel and febantel act synergistically against all relevant nematodes (ascarids and hookworms) in dogs. In particular, the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala and Ancylostoma caninum. The spectrum of activity of praziquntel covers also cestode species in dogs, in particular all Taenia spp. and Dipylidium caninum. Praziquantel acts against adult and immature forms of these parasites.

Perorally administered praziquantel is absorbed almost completely from the intestinal tract. After absorption, the drug is distributed to all organs. Praziquantel is metabolized into inactive forms in the liver and secreted in bile. It is excreted within 24 hours to more than 95% of the administered dosage. Only traces of non-metabolised praziquantel are excreted.

The pamoate salt of pyrantel has low aqueous solubility, an attribute that reduces absorption from the gut and allows the drug to reach and be effective against parasites in the large intestine. Because of the low systemic absorption of pyrantel pamoate, there is very little danger of adverse reactions/toxicity in the host. Following absorption, pyrantel pamoate is quickly and almost completely metabolized into inactive metabolites that are excreted rapidly in the urine.

Febantel is absorbed relatively rapidly and metabolized to a number of metabolites including fenbendazole and oxfendazole, which have anthelmintic activity.

Anthelmin Plus Flavour Vm 01656/4015

Anthelmin Plus XL Vm 01656/4016