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Contra-indications, warnings, etc
Do not use in dogs suffering from perforation of the tympanic membrane. Before treating with the product, the integrity of the tympanic membrane must be verified.
Do not use in cases of hypersensitivity to the active substances, to other azole antifungal agents or to any other fluoroquinolones or to any of the excipients.
Do not use in animals, where resistance of causative agents to marbofloxacin and/or clotrimazole is known.
Do not administer to pregnant or lactating bitches.
Avoid contact with eyes in animals. In case of accidental contact, rinse thoroughly with water.
Before treating with the product, the integrity of the tympanic membrane must be verified. Use of the product should be based on susceptibility testing of the bacteria and/or fungi isolated from the animal. If this is not possible, therapy should be based on local (regional) epidemiological information about susceptibility of the target pathogens.
Official and local antimicrobial policies should be taken into account when the veterinary medicinal product is used. Heavy reliance on a single class of antibiotic may result in the induction of resistance in a bacterial population. It is prudent to reserve the fluoroquinolones for the treatment of clinical conditions which have responded poorly, or are expected to respond poorly, to other classes of antibiotics.
Prolonged and intensive use of topical corticosteroid preparations is known to trigger local and systemic effects, including suppression of adrenal function, thinning of the epidermis and delayed wound healing.
Quinolone class drugs have been associated with cartilage erosions in weight-bearing joints and other forms of arthropathy in immature animals of various species. The use of the product in young animals is not recommended.
Adverse reactions
Usual adverse reactions associated with corticosteroid drugs may be observed (changes in biochemical and haemotological parameters, such as increase in alkaline phosphatase, and of aminotransferase, some limited neutrophilia).
On rare occasions, the use of this combination may be associated with deafness, mainly in elderly dogs and mostly of a transient nature.
Changes in biochemical and haematological parameters (such as increase of alkaline phosphatase, aminotransferase, some limited neutrophilia, eosinopaenia, lymphopaenia) are observed with three fold the recommended dosage; such changes are not serious and will reverse once the treatment has stopped.
User Safety
Wash hands carefully after applying the product.
Avoid contact with eyes. If splashed in the eye, rinse with large amounts of clean water.
If skin or eye symptoms persist, or the product is accidentally swallowed, seek medical attention and show the package insert to the physician.
People with known hypersensitivity (allergy) to (fluoro)quinolones, (cortico)steroids or antifungals and to other ingredients in the product should take care to avoid contact with the product during administration.
Environmental Safety
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.