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Further information
In a study of 11 Lacaune breed ewes, ovulation occurred between 42 and 58 hours following eCG injection, with the majority (73%) ovulating between 50 and 54 hours. In the case that artificial insemination and advanced breeding techniques (e.g. embryo transfer) are applied, the timing of ovulation should be taken into consideration for the selected technique for optimal results.
The safety of the veterinary medicinal product has not been established during lactation. Use only according to the benefit/risk assessment by the responsible veterinarian.
The pharmacokinetic profile of progesterone when administered as a single device was characterised by a maximum concentration (Cmax) in plasma of up to 5.9 ng/ml achieved post-dosing. Peak concentrations were followed by a decline in systemic exposure to a steady state of approximately 2 ng/ml. After removal of the device, circulating blood levels of progesterone fall precipitously within 2-4 hours reaching baseline levels by 12 hours.