Target species
Cattle
Indications for use, specifying the target species
Formulated for use in the dairy cow at the point of drying off, that is, immediately after the last milking of the lactation, in order to treat existing mastitis and to provide protection against further infections during the dry period.
A useful aid in reducing the incidence of summer mastitis in heifers and dry cows at risk.
Active against both Gram-positive and Gram-negative organisms which are associated with mastitis and is effective against Streptococcus agalactiae and other Streptococcus species, penicillin resistant and sensitive Staphylococci, Corynebacterium, Arcanobacteria species, Escherichia coli and other susceptible Gram- negative bacteria.
Cloxacillin benzathine and ampicillin trihydrate in a long-acting base maintain effective antibacterial levels in the dry cow udder for up to 10 weeks and are non-irritant to udder tissue.
Contraindications
None.
Special Warnings for each target species
None known.
Special precautions for use
Special precautions for use in animals
When infusing heifers it is important that the syringe nozzle is not introduced into the teat. The recommended procedure is as follows:
The animal(s) should be properly restrained. The teats are cleaned and disinfected. The teat orifice is located and the nozzle of the syringe placed against it but NOT inserted. When the syringe plunger is depressed the antibiotic passes easily through the teat into the udder.
Official national and regional antimicrobial policies should be taken into account when the product is used.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Protective gloves should always be worn when infusing heifers, to avoid skin contact with the product.
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
Sensitised individuals or those advised not to work with such preparations should not handle this product.
This product should be handled with great care to avoid exposure, taking all recommended precautions.
Should symptoms develop following exposure such as skin rash, medical advice should be sought. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.
Wash hands after use.
Adverse reactions (frequency and seriousness)
None known.
Use during pregnancy, lactation or lay
Safe for use during pregnancy.
Interaction with other medicinal products and other forms of interaction
None known.
Amounts to be administered and administration route
Dry Off Therapy: After the final milking of a lactation, clean and disinfect the teats and introduce the contents of one tube into each quarter via the teat canal. Avoid contamination of the syringe nozzle.
When infusing heifers it is important that the syringe nozzle is not introduced into the teat. The recommended procedure is as follows:
The animal(s) should be properly restrained. The teats are cleaned and disinfected. The teat orifice is located and the nozzle of the syringe placed against it but NOT inserted. When the syringe plunger is depressed the antibiotic passes easily through the teat into the udder.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Not applicable.
Withdrawal period
Do not use in cows with a short dry period.
Not intended for use within 49 days of calving.
Milk for human consumption may only be taken from 156 hours after calving.
Should a cow calve earlier than 49 days after the last treatment, milk for human consumption may only be taken from 49 days plus 156 hours after the last treatment. Should a cow calve earlier than 49 days after treatment, consult your veterinary surgeon.
In cows suffering from hypocalcaemia it may be necessary to withhold milk for a longer period than that stated above. In such cases, milk should be withheld until the levels of antibiotics are below the maximum accepted residue levels, i.e. 0.03 mcg/ml for cloxacillin and 0.004 mcg/ml ampicillin.
Animals must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only 28 days from the last treatment.
The product must not be used in the treatment of lactating cows. Should this occur milk should be discarded for 30 days, following which time milk should be tested until antibiotic can no longer be detected.
Must not be used in the treatment of lactating cows.