ATC Vet Code: QJ01FF02

The mode of action is inhibition of protein synthesis at the ribosomal 50S subunit level. Lincomycin is primarily excreted in the faeces as both parent compound and metabolites with large biliary contribution. After administration of the recommended single dosage, faecal excretion accounts for 38% and urinary excretion for 49% of the total dose. The antibiotic is transported in polymorphonuclear leucocytes to the site of infection, an event that may explain the efficient penetration and targeting of organisms in tissues difficult to reach by diffusion in the presence of purulent material.