Indications for use, specifying the target species
The treatment and control of gastrointestinal nematodes, and lungworms and nasal bots of sheep
Gastrointestinal worms (adult and immature):
Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus spp, Cooperia spp, Nematodirus spp including N. battus, Strongyloides papillosus, Oesophagostomum spp, and adult Chabertia ovina.
Inhibited larval stages and benzimidazole resistant strains of H. contortus and Ostertagia circumcincta are also controlled.
Lungworms (adult and immature):
Nasal bot (all larval stages):
The product has been formulated specifically for use in sheep. It should not be used in other species, as adverse reactions, including fatalities in dogs, may occur.
The product is not for intravenous or intramuscular use.
Special Warnings for each target species
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
•Too frequent and repeated use of anthelmintics from the same class, over an extended period of time
•Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device (if any)
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Resistance to ivermectin (an avermectin) has been reported in Teladorsagia in sheep and goats within the EU and it is common in Haemonchus in sheep outside the EU. Therefore the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.
Special precautions for use
Special precautions for use in animals
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Do not smoke, drink or eat while handling the product.
Avoid contact with skin and eyes. In case of accidental eye or skin contact, wash the affected area with clean running water immediately. Seek medical attention if irritation persists.
Wash hands after use.
Adverse reactions (frequency and seriousness)
Some animals may cough slightly immediately after treatment. This is a temporary occurrence and is of no clinical consequence.
Use during pregnancy, lactation or lay
The product can be administered to ewes at any stage of pregnancy or lactation provided that the milk is not used for human consumption.
Interaction with other medicinal products and other forms of interaction
Amounts to be administered and administration route
Ivermectin should be administered at a dosage rate of 200 μg per kg bodyweight (2.5 ml per 10 kg bodyweight). It should be administered orally. It is recommended that a suitably calibrated dosing gun is used to allow accurate dosing especially in young animals.
To ensure administration of a correct dose, body weight should be determined as accurately as possible; accuracy of the dosing device should be checked.
Do not mix with other products.
Overdose (symptoms, emergency procedures, antidotes), if necessary
No antidote has been identified, however symptomatic treatment may be beneficial.
Sheep may not be slaughtered for human consumption until 14 days after the last treatment.
Do not use in sheep producing milk for human consumption.