Do not use in cases of known hypersensitivity to the active substance or any of the excipients.
For environmental reasons:
Not to be used in veal calves.
Do not administer to dairy calves weighing more than 80 kg bodyweight or to bull beef or suckler calves weighing more than 150 kg bodyweight.
Not to be used to treat bull beef calves less than 3 months old.
For more information see environmental safety section.
It is recommended to treat all animals in a pen.
Hygienic measures may reduce the risk of coccidiosis. It is therefore, recommended to improve concomitantly the hygienic conditions in the concerned facility, particularly dryness and cleanliness.
To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.
To alter the course of an established clinical coccidial infection, in individual animals already showing signs of diarrhoea, additional supportive therapy may be required.
Treatment during an outbreak will be of limited value for the individual animal because of damage to the small intestine having already occurred.
As with any antiparasiticide, frequent and repeated use of antiprotozoals from the same class may lead to the development of resistance.
In pigs there is no interaction in combination with iron supplementation.
A threefold overdose is well tolerated by healthy piglets and calves without signs of intolerance.
No signs of overdose have been observed in lamb safety studies with threefold overdose at a single treatment and twofold overdose treatment on 2 consecutive days.
Withdrawal period(s)
Cattle
Meat and offal: 63 days
Not permitted for use in lactating animals producing milk for human consumption.
Pigs
Meat and offal: 77 days
Sheep
Meat and offal: 42 days
Not permitted for use in lactating sheep producing milk for human consumption.
User Safety
People with known sensitivity to the active substance or any of the excipients should avoid contact with this product.
Avoid skin and eye contact with the product.
Wash any splashes from skin or eyes immediately with water.
Do not eat, drink or smoke while using the product.
Environmental Safety
The major metabolite of toltrazuril, toltrazuril sulfone (ponazuril), has been shown to be both very persistent (half-life ca. 1 year) and mobile in soil and to be toxic to plants.
For environmental reasons:
Cattle: For dairy calves: In order to prevent any adverse effects on plants and possible contamination of groundwater, manure from treated calves must not be spread onto land without dilution with manure from untreated cows. Manure from treated calves must be diluted with at least 3 times the weight of manure from mature cows before it can be spread onto land.
Sheep: Lambs kept throughout the whole life span indoors under an intensive rearing system must not be treated beyond the age of 6 weeks or body weight of more than 20 kg at treatment. Manure from these animals should only be applied to the same piece of land every third year.
Pigs: None
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.