Pharmacotherapeutic group: Prostaglandins. ATCvet code: QG02AD01.
Dinoprost (as trometamol) has a luteolytic activity and provokes the involution of the corpus luteum in most mammalian species and the appearance of oestrus and ovulation in females having a cyclic sexual activity. Administration of dinoprost provokes abortion or parturition in bovine and porcine species. Moreover, it has other activities, which vary according to the different species such as increase of blood pressure and bronchial constriction. Dinoprost is also a stimulant of smooth muscle fibres.
In all the species, dinoprost (or PGF2 α) is rapidly absorbed from the injection site. The maximum concentrations (Cmax) in plasma of 13,14-dihydro-15-keto-prostaglandin F2alpha (PGFM), the major metabolite of PGF2 α, are around 15 µg/L for bovine and 382 µg/L for porcine and are obtained after 19 min for bovine and after 10 min for porcine.