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Clinical particulars
Target species
Apralan G200 Premix is indicated for use in young pigs.
Indications for use, specifying the target species
For the treatment and control of bacterial enteritis in young pigs caused by Escherichia coli and other apramycin sensitive organisms.
In vitro, the following organisms were susceptible to apramycin at concentrations of 16 µg/ml or less:
i) Gram-positive bacteria
Staphylococcus aureus.
ii) Gram-negative bacteria
Bordetella bronchiseptica
Escherichia coli
Campylobacter spp
Klebsiella spp
Salmonella spp
Proteus spp
Pseudomonas aeruginosa
Shigella sonnei
iii) Mycoplasma
Mycoplasma hyopneumoniae
Do not use in cases of known hypersensitivity to apramycin.
Do not use in cats.
Special warnings for each target species
Special precautions for use
i. Special precautions for use in animals
Official, national and regional antimicrobial policies should be taken into account when the product is used.
ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals
Avoid inhaling the powder while preparing the medicated feed.
Avoid contact with skin and eyes. In the event of skin contact, wash thoroughly with soap and water.
In the event of accidental eye contact, wash the affected eye with fresh running water and seek medical attention if irritation persists. Wash hands after use.
Adverse reactions (frequency and seriousness)
None known.
Use during pregnancy, lactation or lay
Apralan G200 Premix is not intended for use in pregnant or lactating animals. However, laboratory studies in the rat and rabbit have not produced any evidence of a teratogenic effect.
Interaction with other medicinal products and other forms of interaction
None observed.
Amounts to be administered and administration route
For oral administration.
The dose is 4-8 mg kg bodyweight. To achieve this, thoroughly mix 0.5 kg of Apralan G200 Premix in one tonne of finished feed to provide 100 ppm apramycin activity. It is recommended to first thoroughly mix 1 part of product to 20 parts of feed (e.g. 0.5 kg of Apralan G200 Premix to 10 kg feed) before incorporation into the finished feed. The product can be incorporated into pelleted feed preconditioned with steam for up to 15 minutes at a temperature of not greater than 75°C.
The intake of medicated feed depends on the clinical condition of the animals. In order to obtain the correct dosage, the concentration of Apralan G200 has to be adjusted accordingly.
Feed as the only ration for a maximum of 28 days or as directed by the veterinary surgeon.
For incorporation into dry feed at the registered mill.
A manufacturer who is approved to incorporate directly at any concentration, veterinary medicinal products or premixtures containing such products must be responsible for mixing when incorporation is less than 2kg per tonne for final feed.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Groups of five male and five female four-week old pigs received apramycin ad libitum in the feed at up to 550 ppm for 28 days. No reactions were detected.
Withdrawal period(s)
Meat: 14 days