Pharmacotherapeutic group: Anti-infective for systemic use
ATCVet Code: QJ01XQ01
Pharmacodynamic properties
Tiamulin hydrogen fumarate is a semi-synthetic diterpene antibiotic. The mode of action is by inhibition of ribosomal protein synthesis in sensitive bacteria. It is a bacteriostatic antibiotic and the following organisms show sensitivity in vitro:
Brachyspira: Brachyspira hyodysenteriae, B. pilosicoli
Mycoplasmas: Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae, Ureaplasma spp., M. gallisepticum, M. synoviae, and M. meleagridis.
Gram-positive: Staphylococcus spp., Streptococcus spp., Arcanobacterium pyogenes.
Gram-negative: Pasteurella spp., Klebsiella pneumoniae, Actinobacillus (Haemophilus) spp., Fusobacterium necrophorum, Bacteroides spp., Campylobacter coli, Lawsonia intracellularis.
Pharmacokinetic properties
Following oral administration, tiamulin hydrogen fumarate is rapidly absorbed and peak serum concentrations are achieved 2 - 4 hours after administration and concentrates in some tissues e.g. lung. Following administration, it is rapidly metabolised and excreted.